Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"persistent pain"”.
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Investigating the Contribution of the Inflammasome to Persistent Pain States
Neuropathic pain, a debilitating condition, occurs as a consequence of nerve injury with symptoms such as spontaneous pain, hyperalgesia, and allodynia commonly reported. In animal models of peripheral nerve injury, there is accumulation and proliferation of microglial cells in the injured spinal …
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Portraits of persistent pain: a portfolio of work relating to the 'problem of pain'
Chronic pain is a mysterious and challenging problem that affects a significant number of people in a significant number of ways. Perhaps one of the greatest challenges of these conditions is the highly subjective nature of pain, coupled with the apparent absence of any observable abnormality. In …
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Informatics Intervention for Self-Management of Pain after TBI
… and troublesome symptom following TBI is persistent pain, defined here as pain due to a health condition, disease process, injury or surgery that lasts beyond the normal period of healing, is resistant to treatment, includes physiological maladaptation, continues for at least 3 months, and …
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‘The Agony & the Ecstasy: Managing a Chronic Pain Condition Whilst Being a Mother’
Persistent pain is a debilitating condition affecting more women than men, and for women in their child-rearing years this means struggling to bring up children whilst contending with an unforgiving pain condition. Existing research in this area has found increased levels of pain complaints in …
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Autoradiographic Localization of Carbachol-Induced Second Messenger Response in the Rat Spinal Cord Following Inflammation.
This study examined central mechanisms of persistent pain using an autoradiographic technique to localize phosphoinositide hydrolysis (PI) in the rat spinal cord dorsal horn. The lateral half of laminae I-II showed the highest levels of baseline PI turnover and carbachol-stimulated PI turnover in …
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Mechanisms of pain processing: spinal protein translation in the rat
The word ‘pain’ is described by the International Association for the Study of Pain (IASP) as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Shifts in pain thresholds and responsiveness are an expression of …
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Investigating the Experiences of Evangelical Couples Coping with Painful Intercourse During Early Marriage
… purity messages face heightened risk for persistent pain or difficulty with penile-vaginal intercourse. Drawing on research in communication, psychology, and sexual medicine, the aim of this multilevel qualitative study is to increase understanding of how evangelical couples …
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The impact of modifying attentional bias on vulnerability to pain
… bias” - is thought to confer vulnerability to pain. The current thesis tested this putative mechanism by modifying the bias using the visual-probe task (attentional bias modification; ABM) and examining effects of this experimental manipulation on attentional bias and critical pain outcomes. …
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PARTIAL SPINAL NERVE LIGATION ALTERS ANATOMICAL COMPONENTS OF OXYTOCIN SIGNALING AND THE LEVEL OF TONIC OXYTOCIN-MEDIATED INHIBITION OF NOCICEPTION
Chronic pain affects more than 25 million people in the United States of America, with neuropathic pain contributing to pain in 6-8% of this population. Chronic pain occurs after surgical interventions in approximately 10-40% of patients, but most patients recover without developing persistent …
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Critical role of ROS in capsaicin-induced hyperalgesia
… oxygen species (ROS) are critically involved in persistent pain primarily through spinal mechanisms, thus suggesting ROS involvement in central sensitization. To investigate ROS involvement in central sensitization, the effects of ROS scavengers and donors on pain behaviors were examined in mice. …
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CNAS' Ratings of Nursing Home Residents' Pain: The Role of Empathy
… impairment may experience undertreatment of persistent pain (Fain et al., 2017). Certified nursing assistants (CNAs) are important sources of information about resident pain as provide the majority of residents' hands-on care. Therefore, assessing the accuracy of CNAs' pain assessments and …
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Establishing a Rodent Model of Postoperative Pain: Investigating Potential Sex Differences and Changes in Gene Expression
Chronic pain is a debilitating condition affecting many Canadians. Developing new treatments requires improved understanding of the mechanisms underlying persistent pain. However, preclinical pain research is limited by poor translatability and the underrepresentation of females. To address this, …
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The Relationship Between Menopausal Status and Pain After Breast Cancer Surgery
… in moderate-to-severe acute postoperative pain (APOP), and in some patients transitions into chronic pain. Given that pain is influenced by a multitude of biopsychosocial factors, it is important to continue identifying those which affect individual postoperative pain (POP) experiences. …
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IN-SITU PATIENT WEIGHT SENSOR MEASUREMENT SYSTEM FOR HOSPITAL BEDS
… purposes. Weighing immobile patients has been a persistent pain point in patient care for the past few decades as regular weight measurements of immobile patients pose major difficulties for nurses. Nurses have a high prevalence of musculo-skeletal disorders, of which 30% of injuries arise from …
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Does distress predict central sensitisation in people living with HIV?
Background Persistent pain is a frequent complaint associated with compromised mental health in many people with HIV (PWH). Central sensitisation (CS) is a hallmark of most persistent pain conditions. Pain and psychosocial distress (PSD) appear to have a bidirectional relationship. Therefore, it is …
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Health (Internal-External) Locus of Control in Patients With Soft Tissue Chronic Pain, and Treatment With Art Therapy
<p>Specialists working in the field of Chronic Pain Treatment, have taught the general medical community that the old approach of treating chronic pain as acute pain has created a host of problems for the chronic pain patient, including poor recovery rates, drug addiction, increased and persistent …
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Improving clinical outcomes in rheumatoid arthritis: a patient centred approach
… spanning other symptoms like fatigue and pain and the way their health care is delivered. This thesis used qualitative and quantitative research methods to address three inter-related aspects of clinical care. Firstly, identifying critical challenges for providing patient-centred care. …
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Reflections beyond words: using auto-driven photo-elicitation to explore the pain management programme journey
… the population are estimated to be affected by persistent pain, a long-term complex condition which can have serious implications for an individual’s everyday functioning and quality of life. A biopsychosocial approach to care and pain management programmes can be adopted as a treatment option. …
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The Association between Symptoms of Autoimmune Diseases and Circadian Clock Disruption: A Pilot Study Using Only Healthy Controls
… experienced by RA, MS, SS patients include persistent pain and complaints of sleep and fatigue. Collectively, this thesis aims to validate emerging tools measuring circadian clock disruption as a means of early diagnosis and an accurate prediction of autoimmune disease trigger and …
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Cortical Reorganisation in Complex Regional Pain Syndrome (CRPS)
Complex Regional Pain Syndrome (CRPS) is a debilitating pain condition of unknown aetiology, usually occurring post-traumatically. Early diagnosis of CRPS remains a challenge with adverse implications on rehabilitation and recovery. The main goals of my research were to help develop clinically …
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