Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"peroxisome-proliferator-activated receptor γ (PPARγ)"”.
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Defining Novel Clusters of PPAR gamma Partial Agonists for Virtual Screening
Peroxisome proliferator-activated receptor γ (PPARγ) is associated with a wide range of diseases, including type 2 diabetes mellitus (T2D). Thiazolidinediones (TZDs) are agonists of PPARγ which have an insulin sensitizing effect, and are therefore used as a treatment for T2D. However, TZDs cause …
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The Influence of Growth Stage on Carcass Composition and Factors Associated with Marbling Development in Beef Cattle
… western blot analysis of lipoprotein lipase, AMP activated protein kinase α (AMPKα), stearoylcoenzyme A desaturase (SCD), peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding protein β, and myostatin. Carcass data were recorded and LM samples were collected and aged 2, 7, …
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The Influence of Chromium Supplementation on the Insulin Pathway, Carcass Traits, and Meat Quality of Feedlot Steers
… analysis. Biopsies were used to analyze peroxisome proliferator activated receptor γ (PPARγ), protein kinase B (Akt), phospho- Akt, and ribosomal protein S6 kinase 1 (p70S6K) abundance and glucose transporters (GLUT) 4 and 1 gene expression. Experiment 1 showed an increase in dressing …
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… tissue of 56-day-old HWS than LWS. Expression of peroxisome proliferator-activated receptor γ (PPARγ) in all adipose tissue depots was greater (P < 0.05) in LWS than in HWS chickens. The HWS chickens had larger (P < 0.0001) and fewer (P < 0.0001) adipocytes per unit area than LWS. These results …
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Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents
… artery. LPA is the ligand of eight GPCRs and the peroxisome proliferator-activated receptor γ (PPARγ). We pursued a gene knockout strategy to identify the LPA receptor subtypes necessary for the neointimal response in a non-injury model of carotid remodeling and also compared the effects of AGP …
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Testing the metabolic sink postulate: subcutaneous adipose tissue the protective depot
… fat removal and glucose homeostasis. Peroxisome proliferator-activated receptor-γ (PPARγ; an activator of adipogenesis) knockout mice and control mice received either Sham surgery or intra-abdominal lipectomy. The inability of cell proliferation following lipectomy in PPARγ knockout …
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
… <p>Previous results from our lab determined that peroxisome proliferator activated receptor γ (PPARγ) has reduced expression and activity in the kidney of OP vs. OR rats. Therefore, in the second aim we investigated the effect of PPARγ ligand activation on expression and activity of proximal …
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Reduced corticosteroid sensitivity in smokers with asthma: potential mechanisms and treatment
… with asthma. Agonists of the nuclear hormone receptor peroxisome proliferator activated receptor-γ (PPARγ) have been demonstrated to be effective at reducing inflammation in both in-vitro and animal models of asthma. Therefore to examine the hypothesis that PPARγ stimulation would reduce the …
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Studies on the mode of action of dermonecrotic toxins: Effects on adipogenic signaling pathways and delivery of c-terminal cargo into the cytosol
The dermonecrotic toxin family consists of the dermonecrotic toxin from Bordetella spp. (DNT), the cytotoxic necrotizing factors from Escherichia coli (CNF1, CNF2 and CNF3) and Yersinia pseudotuberculosis (CNFY), and the mitogenic toxin from Pasteurella multocida (PMT). These relatively large …