Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"perivascular niche"”.
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Adult Neural Stem Cells and Their Perivascular Niche
Stem cells reside in specialized niches that support their selfrenewal and differentiation. A balance between intrinsic and extrinsic signals mediates stem cell quiescence, activation and proliferation. In the mammalian subventricular zone (SVZ), the stem cells are a subset of GFAP+ astrocytes. A …
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Examining Cellular Interactions and Response to Chemotherapy in The Glioblastoma Perivascular Niche
… within the GBM environment is known as the perivascular niche (PVN). We have designed a 3D in vitro model of the PVN comprised of either collagen Type 1 or HyStem-C®, human umbilical vein endothelial cells (HUVECs) or human brain microvascular endothelial cells (HBMECs), and LN229 (GBM) …
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Developing a biomaterial model of the bone marrow perivascular niche for the study of hematopoietic stem cells
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression
… microenvironment. Specifically, the perivascular niche (PVN) of GBM has been shown to facilitate tumor cell invasion and harbor a subpopulation of cancer stem cells, which are implicated in tumorigenesis and disease recurrence. However, the mechanisms by which the PVN promotes disease …
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Bioengineering of Heterogenous Glioblastoma Multiforme Microenvironment
… by a tumor microenvironment (TME) wherein the perivascular niche and hypoxic region are present. The glioblastoma microenvironment (GBME) exhibits high heterogeneity, vast cell-to-cell interactions, and stiff mechanical properties. To produce in vitro models mimicking the GBME features, GBM …
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CROSSTALK BETWEEN TUMOUR VASCULATURE AND OVARIAN CANCER STEM CELLS: THE ROLE OF L1CAM.
… microenvironment (TME) is thought to act as a niche for OCSC, preserving stem cells properties and sustaining tumour recurrence. The crosstalk between TME and OCSC, therefore, offers a source of new targets and mechanisms to overcome the limitations of current treatments. We identified L1CAM, …
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Glioblastoma: multifaceted immunosuppression mediated through galectin family members
… and 0.0087) with T-cells located in the perivascular niche (p=0.0932). Additionally, 22% of tumours contained T-cell aggregations. Galectins 1, 3, 4 and 7 were also found in the majority of GBM assayed; immune checkpoints galectin-9 and PD-L1 were found in 100% and 50% of assayed tumours, …
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Optimizing a 3D brain microvascular model to study radiation damage
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01