Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"peripherin"”.
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Characterization of Peripherin Isoforms in Amyotrophic Lateral Sclerosis
Peripherin is a type III intermediate filament protein that is predominately expressed in the peripheral nervous system and in subsets of efferent projections in the central nervous systems. While the exact role of peripherin remains unclear, it is found upregulated after traumatic neuronal injury …
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The Role of Peripherin in Photoreceptor Outer Segment Morphogenesis
… centers on elucidating the molecular role of peripherin/retinal degeneration slow (rds) in outer segment disc morphogenesis, including study of peripherin/rds trafficking from its site of synthesis in the endoplasmic reticulum to its site of function in the outer segment. Peripherin/rds is …
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Molecular mechanisms underlying morphological effects of protein kinase C under normal conditions and cellular stress.
… proteins, including the intermediate filament peripherin and several mRNA-binding proteins. Peripherin and three RNA-binding proteins G3BP2, PABPC1, and IGF2BP3 were further investigated regarding their putative function in PKCε-mediated neurite outgrowth. However, no involvement could be …
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Estrogen Signaling in Trigeminal Nociception
… sub-populations, we co-localized GPR30 with peripherin and NFH using double label immunohistochemistry. GPR30 showed a high degree of overlap with peripherin and partial overlap with NFH, indicating that GPR30 is preferentially expressed in neurons with unmyelinated axons. ERK activation by …
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Identification and Application of Novel Therapeutic Targets for PRPH2-Associated Disorders
… in the photoreceptor specific tetraspanin Peripherin-2 (PRPH2) are some of the most pervasive pathogenic inherited retinal disease mutations with over 200 identified. Lack of an FDA approved treatment, numerous low prevalence mutations, and complex pathogenic mechanisms make it imperative …
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Bioactive Peptides as Antibacterial Agents and Visual Transduction
… will be discussed in greater detail. Secondly, peripherin 2 (PRPH2) is a photoreceptor specific glycoprotein essential for proper formation of the rod and cone photoreceptor outer segments of the retina, which are the organelles responsible for visual transduction. Defective or absent PRPH2 …
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Role of oxidative stress in photoreceptor degeneration
… (atrdl/atrdl), rhodopsin knockout (R/?c/ ~) and peripherin/retinal degeneration slow (rds/rds) were firstly investigated for evidence of oxidative damage by analysis of oxidative stress markers. Secondly, the mutants were crossed to a superoxide dismutase 2 heterozygous mouse (Sod2+/~), with …
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Molecular Dissection of Multifunctional Proteins in Rod Outer Segments
… a targeting motif from an unrelated protein, peripherin. Furthermore, we obtained surprising evidence that rhodopsin's role in this process is limited to providing an abundance of transmembrane protein material to disc membranes.</p><p>Finally, while attempting to find a targeting motif to …