Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"peripheral sensitization"”.
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Mechanisms of Peripheral Sensitization in Inflammatory Knee Pain
… neurons (knee neurons), through a process called peripheral sensitization, underlies arthritic knee pain. My research goal was to elucidate the mechanisms of knee neuron peripheral sensitization by developing and utilizing several in vitro and in vivo disease models. Since experimental animal …
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Central Role Of CGRP And Protein Kinase A In Promoting Trigeminal Sensitization In An In Vivo Model Of Temporomandibular Joint Disorder
… of primary nociceptive neurons that promote peripheral sensitization and excitation of second order neurons implicated in the development of central sensitization and hyperalgesia. Elevated levels of the neuropeptide calcitonin gene-related peptide (CGRP) in the joint capsule and upper spinal …
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Secondary Traumatic Stress Promotes Peripheral Trigeminal Nociceptor Sensitization
… an attack, leads to hyperalgesia and allodynia. Sensitization and activation of peripheral trigeminal neurons that provide sensory innervation to most of the head and face is implicated in migraine pathology. The most commonly cited risk factor for migraine is stress, and in particular, primary …
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Regulation of Neuropeptide Y, Vasoactive Intestinal Polypeptide, and Their Receptors in Trigeminal Ganglion Neurons and Glia in Response to Adjuvant-Induced Inflammation
… to contribute to TMJ pathology and contribute to peripheral sensitization within the ganglion.</p>
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Identification of Connexins in Facilitating Neuron-Satellite Glial Cell Signaling in Trigeminal Ganglia
… different models of inflammation: acute, acute-sensitization, and chronic. Initially, quantitative PCR was used to demonstrate that mRNA for Cxs: 26, 29, 36, 37, 40, 43, 50, and 57 was expressed in TG under basal conditions. Next, protein expression of Cxs: 26, 32, 36, 40, 43, 46, and 50 was …
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Characterization of an in Vivo Model of Temporomandibular Joint Inflammation
… to contribute to TMJ pathology and contribute to peripheral sensitization within the ganglion.
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FARMACI ANALGESICI ED ANTIINFIAMMATORI PER LA TERAPIA DEL DOLORE IN DIVERSE SPECIE ANIMALI DI INTERESSE VETERINARIO
… manage various types of pain. Besides to their peripheral anti-prostaglandin effects, that make them the first choice for minimizing development of peripheral sensitization of nociceptors, NSAIDs are considered to have central-acting analgesic effects, thanks to the inhibition of cyclooxygenase …
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Assessing the Role of the Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channel in Visceral Sensation
Abdominal pain is a significant clinical problem impacting many individuals including patients with inflammatory bowel disease (IBD). Current therapeutics for IBD-related pain include opioids which are addictive and associated with increased mortality in IBD patients. Thus, novel mechanisms for …
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Development and Characterization of a Mechanically Induced Temporomandibular Joint Disorder
… jaw opening for 20 minutes results in sustained sensitization of trigeminal nociceptive neurons by a mechanism that likely involves increased expression of cytokines within the spinal trigeminal nucleus.