Global ETD Search
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Showing 1 to 11 of 11 for “"peripheral neuropathies"”.
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Peripheral neuropathies of childhood
Peripheral nerve disease was described by Galen (AD 130-200) over a thousand years ago.(3) Detailed anatomical illustrations were documented by Andreas Vesalius in his major work 'De humani corporis fabrica' in 1543.(4) Over the last two centuries an explosion in knowledge in the area has occurred, …
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Expression of genetic peripheral neuropathies in South African Children
Genetic peripheral neuropathies are described in European ancestries, with a population prevalence of 1:2500-1:10000. However, these diseases are under-reported and poorly understood in African populations. Definite, probable and suspected genetic peripheral neuropathy cases, were characterized …
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The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
… dysfunction has emerged as a common cause of peripheral neuropathies. While the role of neuronal and axonal mitochondria in peripheral nerve disease is well appreciated, whether Schwann cell: SC) mitochondrial deficits contribute to peripheral neuropathies is unclear. Greater insight into the …
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Nerve Fiber Diameter Measurements Using Hematoxylin and Eosin Staining and Brightfield Microscopy to Assess the Novel Method of Characterizing Peripheral Nerve Fiber Distributions by Group Delay
<p>Peripheral neuropathies are a set of common diseases that affect the peripheral nervous system, causing damage to vital connections between various parts of the body and the brain and spinal cord. Different clinical conditions are known to selectively impact various size nerve fibers, which …
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Nervenzupfpräparation (nerve fiber teasing) in der Diagnostik peripherer Neuropathien beim Tier
… TEASING AS A DIAGNOSTIC AID IN DETECTION OF PERIPHERAL NEUROPATHIES – METHODOLOGY AND INTERPRETATION Nerve biopsies are widely used for the investigation of peripheral neuropathies in man and animals in addition to clinical and electrodiagnostic evaluation . Besides light- and electron …
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Med12 Is A Critical Regulator of Neural Crest Lineage and Nervous System Myelination
… system, 2) myelin maintenance in the adult peripheral nervous system, and finally, 3) pigmentation ability of hair melanocytes. Our models provide novel molecular functions and downstream targets of Med12, with a special emphasis on cells of neural crest origin. Moreover, our models …
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The Role Of Adult Stem Cells And Tumor Necrosis Factor In Peripheral Neuropathy
<p>Peripheral neuropathies are a significant cause of morbidity and mortality, with a population prevalence of 2,400 per 100,000 (2.4%) that increases in the elderly to 8,000 per 100,000 (8%)(C. N. Martyn and R. A. Hughes, 1997). The variations in symptom distribution and etiologic attribution have …
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Efeitos dos estímulos elétricos senoidais na resposta induzida cerebral: estudo da seletividade das fibras sensitivas
… important for the evaluation of patients with peripheral neuropathies (ex., leprosy and neuropathic diabetes). Induced brain responses may have applicability as a new alternative in cognitive evaluation to EES (including patients with central lesions, such as in stroke).
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Characterising the roles of mammalian atlastins in the endoplasmic reticulum and beyond
… and Parkinson’s disease, multiple sclerosis, peripheral neuropathies and various motor neuron diseases. This project focuses on endoplasmic reticulum (ER) proteins atlastins (ATLs), particularly ATL1, as *ATL1* gene mutations cause the most frequent childhood-onset form of HSP. Using CRISPRi, …
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Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
Peripheral neuropathies, as the result of nerve damage, are characterized by pain, numbness, and tingling in the extremities and slow nerve conduction. Chemotherapy-induced peripheral neuropathy is a major dose-limiting side effect of many other commonly used chemotherapeutic agents, including …
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Common Pathophysiological Features of Charcot-Marie-Tooth Disease
Hereditary peripheral neuropathy, also known as Charcot-Marie-Tooth disease (CMT) and related disorders, are a group of genetic disorders causing length-dependant neuropathy, resulting in motor and/or sensory loss progressing from the lower extremities toward the spine. With a population prevalence …