Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 123 for “"peripheral nervous system"”.
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Role of Laminins in the Development of the Peripheral Nervous System
<p>To investigate the function of laminins in peripheral nerve development, the laminin γ1 gene was specifically disrupted in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking …
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Electronic bidirectional interfaces to the peripheral nervous system for prosthetic applications
… devices for neural signal acquisition and Peripheral Nervous System (PNS) stimulation. The final aim of the project in which this work is involved is in fact the realization of a prosthetic hand controlled using neural signals. The commercially available prosthesis are based on …
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Inflammasome mediated response to biomaterials implanted in the peripheral nervous system
… neurological function in brain, spinal cord or peripheral nerve injury patients. However, neural interfaces require selectivity and long-term stability, which are compromised by the physiological host-implant response (foreign body reaction - FBR), which surrounds the implant with fibrotic …
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Peripheral Nervous System Modulation with Wireless Cellular Sized Freestanding Injectable Devices
… muscle atrophy and toxicity specifically in the Peripheral Nervous System (PNS). This work aims to advance bioelectronic medicine by developing efficient, wireless, cellular- sized electronic devices that can be administered in a drug-like fashion. These innovative, substrate-free nanoelectronic …
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Multiple Myeloma and Its Treatment Alter Peripheral Nervous System Structure and Function
… MYELOMA AND ITS TREATMENT ALTER PERIPHERAL NERVOUS SYSTEM STRUCTURE AND FUNCTION </strong></p> <p>Alyssa Katarina Kosturakis, BA</p> <p>Supervisory Professor: Patrick M. Dougherty, PhD</p> <p>Peripheral neuropathy is among the most deleterious side effects of frontline …
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Immune contributions of the meninges and choroid plexus in animal models of central and peripheral nervous system neuropathy
… as purely structural, protecting the central nervous system (CNS). Similarly, the choroid plexus (CP) was thought to only produce cerebrospinal fluid. Advances have dispelled these limited views, and the meninges and CP are now known as critical sites of immune activity, housing various immune …
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The Role of Sulfatide in the Development and Maintenance of the Nodal and Paranodal Domains in the Peripheral Nervous System
… these mice, it has been shown in the central nervous system (CNS) that sulfatide is essential for normal myelin synthesis and stability even though the onset of myelination is not impaired. Additionally, proper initial clustering of paranodal proteins and cluster maintenance of nodal proteins …
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DEVELOPMENT OF THE LARVAL PERIPHERAL NERVOUS SYSTEM IN THE ASCIDIAN CIONA INTESTINALIS: ROLE OF THE RETINOIC ACID AND FGF/WNT SIGNALLING PATHWAYS AND OF THE POU TRANSCRIPTION FACTORS.
… focuses on the development of the larval peripheral nervous system of the Tunicate Ciona intestinalis with two main aims: a) to understand how the interactions between Retinoic Acid (RA) and the FGF/WNT pathways control its development; b) to study the role played by transcription factors …
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Cellular organisation of peripheral nerve and the neuromuscular junction
The organisation of cells in the peripheral nervous system is crucial for its proper function. Action potential generation, conduction and synaptic transmission to the muscle fibres are dependent not only on cells directly implicated in these functions (i.e. neurons and muscle fibers) but also on …
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A Fiber Count and Caliber Spectral Study of the Cat Ulnar Nerve and Some of Its Branches
Axons of the peripheral nervous system are always ensheathed, some with myelin and neurolemma sheath, others with the latter covering only. Nerve fibers possessing both coverings are spoken of as myelinated. Fibers of the peripheral nervous system surrounded by only the neurolemma sheath are called …
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Die Wechselbeziehungen zwischen der Myelinbildung und dem Phänotyp der Axone im Zentralen und im Peripheren Nervensystem der Säugetiere
… and glial cells in the central as well as the peripheral nervous system, especially with the interrelationship between axonal diameter and myelin sheath thickness.
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CENTRAL NERVOUS SYSTEM CONTROL OF MICTURITION IN RODENTS THROUGH NEUROPROTECTION AND ENDOCANNABINOIDS - DOPAMINERGIC AND CANNABINOID CONTRIBUTION
… consists of reflexes involving the central and peripheral nervous system controlling the bladder and urethra. A better understanding of the underlying contribution of the dopaminergic and cannabinoid systems to the control of micturition could help direct therapeutic modalities for related …
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Axon Degeneration and the Schwann Cell Early Injury Response: A Study in Mouse and Zebrafish
After peripheral nervous system injury, axons degenerate through a process termed Wallerian degeneration and Schwann cells transform into a repair phenotype. Axon degeneration is regulated by a signalling pathway controlled by the pro-degenerative axon death molecule sterile-alpha and …
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ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE
… channels expressed in neurons in the central and peripheral nervous systems. These ion channels are sensors for extracellular pH and contribute to a variety of normal functions including learning and memory, seizure termination, fear, anxiety, and pain. Additionally, ASICs mediate neuron death and …
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Identification Of Neuroblastoma And Its Prognostic Markers Using Raman Spectroscopy
… common cancer of infancy. It is one of several peripheral nervous system tumors, including ganglioneuroma, peripheral nerve sheath tumor, and pheochromocytoma. It is commonly situated on the adrenal gland. It displays similar histology to other small round blue cell tumors, including non-Hodgkin …
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Biosynthesis and Signaling of Glucocorticoids and Progestins and Their Effects on Myelin Synthesis in Schwann Cell/neuronal Co-Cultures
… myelin sheath is a specialized membrane in the nervous system that facilitates the transmission of nerve impulses in a fast and efficient manner. Steroids hormones can be synthesized de novo in the nervous system. The major objective of this research was to identify the steroid signal …
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Nerve Fiber Diameter Measurements Using Hematoxylin and Eosin Staining and Brightfield Microscopy to Assess the Novel Method of Characterizing Peripheral Nerve Fiber Distributions by Group Delay
<p>Peripheral neuropathies are a set of common diseases that affect the peripheral nervous system, causing damage to vital connections between various parts of the body and the brain and spinal cord. Different clinical conditions are known to selectively impact various size nerve fibers, which …
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Axogial communication mediated by soluble neuregulin-1 and bdnf
<p>During peripheral nervous system development, successful communication between axons and glial cells including Schwann cells in peripheral nervous system and oligodendrocytes in central nervous system, is required for the proper functions of both neurons and glia. Three types of …
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