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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 150 for “"peripheral nerve"”.
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KERATIN BIOMATERIAL SCAFFOLDS FOR PERIPHERAL NERVE REGENERATION
Peripheral nerve injury is a relevant clinical concern. Although surgical management of these injuries has improved over time, the current "gold standard" for nerve transection injury, autograft, has many limitations. Nerve conduits are used as an alternative to autograft surgery but they are …
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REPEATED BIPHASIC CONDUCTING CONDUITS FOR PERIPHERAL NERVE REPAIR
Each year 400,000 Americans sustain nerve transection injuries which require surgical intervention for repair. Due to rapid scar formation which blocks nerve outgrowth, there are no treatment options for the approximately 90% of patients who have gaps greater than 3 cm. Resultantly, researchers …
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Regulation of peripheral nerve regeneration by the mTOR pathway
… for regrowth after damage, neurons in the peripheral nervous system: PNS) have a robust ability to regenerate their axons following injury. Successful regeneration depends upon both extrinsic cues in the environment and the activation of intrinsic mechanisms to promote regrowth. A number of …
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INFRARED NEURAL STIMULATION AND FUNCTIONALRECRUITMENT OF THE PERIPHERAL NERVE
Peripheral nerve interfaces have been used to restore motor function to paralyzed limbs. To restore the most natural function to paralyzed muscles requires a very selective interface. Arguably, ideal selectivity would entail independent control over each neuron. Neural interfaces based on …
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Cellular organisation of peripheral nerve and the neuromuscular junction
The organisation of cells in the peripheral nervous system is crucial for its proper function. Action potential generation, conduction and synaptic transmission to the muscle fibres are dependent not only on cells directly implicated in these functions (i.e. neurons and muscle fibers) but also on …
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Assessment and modulation of essential tremor using peripheral-nerve stimulation
… the parameters of electrical stimulation on peripheral nerves using a custom-designed real-time system. I have developed (1) an automatic and quantitative method consisting of three computer-based tasks along with their performance metrics that assess the characteristics of tremor, and (2) a …
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The characterisation of Pax3 expressant cells in adult peripheral nerve
… stem and progenitor cell population. In adult peripheral nerves, Pax3 is reported to be expressed in nonmyelinating Schwann cells, however, little is known about the purpose of this expression. Based on the evidence of its role in other adult tissue stem and progenitor cell maintenance, it was …
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Prolongation of regional anesthesia. Determinants of peripheral nerve block duration
Contains fulltext : 161228.pdf (Publisher’s version ) (Open Access)
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The Role of Slit/Robo Signalling in Peripheral Nerve Regeneration
The role of Slit/Robo signalling in peripheral nerve regeneration. Slit/Robo chemorepulsive signalling has been shown to play a role in axon pathfinding during the development of the central nervous system. There is evidence that Slit/Robo are expressed in the adult intact and injured peripheral …
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Characteristics and usefulness of interfascicular contacts in peripheral nerve recording
… of extracting useful command signals fromnerves. A peripheral nerve interface is generally useful for signal extraction if it (1) exhibits favorable recording characteristics such as signal-to-noise ratio and (2) provides as many independent channels of neural information as possible. We …
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Cell-mediated contraction & induced regeneration of the injured peripheral nerve
… in adult mammalian organs, including the sciatic nerve following neurotmesis. Without experimental intervention the defect closes rapidly via contraction of transected nerve stumps by a thick, cohesive capsule of myofibroblasts (MFB) and subsequent collagen synthesis (scar), leading to a painful …
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Sex-dependent and Sex-independent Gene Regulation after Peripheral Nerve Injury
Peripheral nerve injury (PNI) induces cascades of gene expression changes in the central nervous system (CNS). However, there are still many uncertainties regarding the mechanisms of gene regulation that are sex-dependent and sex-independent. In this study, I examined the sex differences and …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
Introduction. The peripheral nervous system has the remarkable capacity to regenerate and restore function following damage or disease. Instrumental in this regenerative process are macrophages, Schwann cells and the production of inflammatory cytokines. The production of inflammatory cytokines …
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A KETOGENIC DIET AND PHYSICAL ACTIVITY’S EFFECT ON PERIPHERAL NERVE FUNCTION
… alterations in sensation due to early damage of peripheral sensory axons. There have been few therapies proposed to help patients developing metabolic syndrome induced painful neuropathies and those that have been developed often exhibit minimal benefit. While the mechanisms of …
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Influence of implant parameters on the mechanisms of peripheral nerve regeneration
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1998.
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Proteomic comparison of biomaterial implants for regeneration of peripheral nerve tissue
… resulting from the healing of transected peripheral nerve differ in morphological and electrophysiological properties based on the biomaterial implant used to bridge the interneural wound gap. At gap lengths >/=10 mm, impermeable silicone tubes promote little to no nerve regenerate unlike …
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Imaging studies of peripheral nerve regeneration induced by porous collagen biomaterials
… clinically to induce regeneration in skin and peripheral nerves, however still there is no complete explanation about the underlying mechanism. This thesis utilizes advanced microscopy to study the expression of contractile cell phenotypes during wound healing, a phenotype believed to affect …
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Statin-Mediated Attenuation of Chemokine Expression in Peripheral Nerve Vascular Endothelial Cells
… autoimmune disorder that affects the peripheral nervous system. By up-regulating endothelial expression of chemokines and cell adhesion molecules (CAMs), TNF-α facilitates the recruitment and trafficking of autoreactive leukocytes across the blood-nerve barrier and into peripheral …
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Peripheral nerve regeneration through collagen devices with different in vivo degradation characteristics
… than 200,000 people are treated each year for peripheral nerve injuries that require surgery. Functional recovery of motor and sensory capability is limited following autograft, the most common procedure for peripheral nerve repair. Tubulation repair of a transected peripheral nerve presents an …
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