Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"peripheral inflammation"”.
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Functional neuroimaging studies of peripheral inflammation-related depression
… or neuroinflammatory mechanisms, as well as peripheral systemic inflammatory disorders such as rheumatoid arthritis, psoriasis, and cancers. Recent research on the immune mechanisms of depression has reproducibly demonstrated a robust association between biological markers of peripheral …
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Peripheral Inflammation and Activity within Corticostriatal Reward Circuitry: Interactive Roles in Components of Anhedonia during Adolescence
… underlying anhedonia, with a specific focus on peripheral inflammation, corticostriatal reward circuitry, and their interaction, in adolescence. Adolescence is a developmental period marked by significant maturation in both reward-related brain function and immune system activity, rendering it a …
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Investigating peripheral inflammation induced neuroinflammation in the absence of blood-brain barrier breakdown in relation to Alzheimer’s disease
Neuroinflammation is important in Alzheimer’s disease (AD) pathogenesis, with microglia and astrocytes contributing to both inflammatory signalling and neurodegeneration. Peripheral inflammation is increasingly implicated as a potential driver of cognitive decline and accelerated pathology, yet the …
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Mise en évidence du rôle physiologique de la chimiokine CCL2 dans la neurotransmission nociceptive au niveau spinal
… of proinflammatory mediators. It also reduced peripheral inflammation by preventing peripheral transport of SP. We then translated our findings in a model of arthritic pain, closer to the clinical reality of patients with rheumatoid arthritis. Spinal administration of INCB3344 had similar …
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The role of Toll-like receptors in Parkinson's disease
Inflammation in the brain has been strongly implicated in the development and progression of Parkinson’s disease (PD). Neuroinflammation in PD is thought to occur in response to aberrant α-synuclein aggregates, and may be mediated by Toll-like receptors (TLRs). TLRs are pattern recognition …
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Stress and inflammation regulate the kynurenine pathway dioxygenases in a glia‐ and tissue‐specific manner
The inflammation and stress responses are intimately related adaptive responses to pathogens or other stressors upsetting our body’s homeostasis. However, when infections or other stressors persist-or are sufficiently traumatic-our normally adaptive responses become maladaptive compromising our …
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Male-specific mechanisms in a murine model of nociplastic pain
… lasted at least 21 days in the absence of peripheral inflammation, indicating the nociplastic nature of this hypersensitivity. The persistent mechanical hypersensitivity was attenuated by morphine or gabapentin in both sexes but was maintained by sex-specific mechanisms: specifically, by …
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The role of Substance P and its signaling pathways in central sensitization
… the dorsal horn can be triggered in response to peripheral noxious stimuli. After release, substance P binds with neurokinin-1 (NK-1) receptors, which are abundantly expressed in the superficial layers of the dorsal horn. The first part of this study investigates the change in release of SP in …
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Male-specific mechanisms in a murine model of nociplastic pain
… lasted at least 21 days in the absence of peripheral inflammation, indicating the nociplastic nature of this hypersensitivity. The persistent mechanical hypersensitivity was attenuated by morphine or gabapentin in both sexes but was maintained by sex-specific mechanisms: specifically, by …
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Multisystem Effects of Mold Inhalation: A Convergence on the Central Nervous System
… at both 1 and 2 days post inhalation. How peripheral inflammation from mold inhalation causes neuroinflammation is unknown. The mechanisms by which mold is inhaled and cleared implicate the lung, systemic circulation, and gastrointestinal tract as potential areas of immune response. After …
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Neuroinflammation and Cognitive Impairment in the Aged: Implications for Nutritional Intervention
… administered lipopolysaccharide (LPS) to mimic a peripheral infection. The excessive production of inflammatory cytokines such as interleukin (IL)-1beta within the brain is proposed to underlie acute cognitive disorders in elderly individuals with a viral or bacterial infection. In initial studies …
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ULTRA-LOW LEVEL SOLUBLE P24 IS ASSOCIATED WITH INFLAMMATION IN PEOPLE WITH HIV ON LONG-TERM VIROLOGICALLY SUPPRESSIVE ANTIRETROVIRAL THERAPY
… antiretroviral therapy (ART), residual inflammation persists in people with HIV (PWH), thus driving higher risk of serious non-AIDS events (SNAEs) and mortality. Circulating HIV proteins have been detected in some suppressed PWH, as an expression of the persistence of the …
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Interleukin-6 trans-signaling: implications for neuroinflammation and cognitive deficits in the aged
In the event of peripheral infection, aged mice exhibit a heightened central inflammatory cytokine response, as well as prolonged behavioral and cognitive deficits when compared to adults. This is attributed to a population of activated or “primed” microglia that produce excessive amounts of …
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The Gut Microbiome as a Novel Approach for Reversing Long-Term Inflammation and Accelerated Aging Across the Lifespan
… and a loss of microglial homeostasis. Persistent peripheral inflammation in children with a history of HIE is recognized but its ramifications, including accelerated aging, are poorly understood. As this coincides with critical stages of brain development, interventions started months or years …
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Brain Endothelial Cells Orchestrate an Anti-Encephalitic State in the Central Nervous System in Response to Peripheral Viral Infection
… CNS. Neurovirulent WNV infection elicits hyperinflammation in the CNS, leading to deleterious clinical outcomes including weakness, memory loss, paralysis, and death. Fortunately, only 1% of individuals infected with WNV progress to the encephalitic stage, although the reasons for this …
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An investigation of a neuro-inflammatory profile of HIV-associated neurocognitive disorders
… with HAND; in particular, it has been noted that inflammation persists despite the successful treatment with antiretroviral therapy (ART). However, the nature to which (neuro)inflammation influences cognitive performance and brain integrity remain unclear. Further, it is not clear how sequence …
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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models
… factors and that vascular dysfunction and inflammation play a role in the progression of the disease. Many cardiovascular factors associated with an increase in systemic infection have been linked to a risk of AD development and progression. However, the link between vascular risk factors, …
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Altered Expression of Metabolic Proteins Contributes to Neuropathological Disease
… mouse models of AD often display alterations in peripheral metabolism. Since insulin is primarily derived from the periphery it is likely that peripheral alterations can lead to alterations in central nervous system (CNS) insulin signaling and that these changes contribute to cognitive decline. …
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Effects of dietary intervention on inflammation and intrauterine growth restriction in neonatal piglets
… children also have an increased risk for chronic inflammation and psychiatric diseases later in life. Inflammation during early development is associated with psychiatric disease risk by disrupting normal neurodevelopmental processes. Due to the potentially devastating effects of IUGR, it is …
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The Role of MICRORNAs on Systemic and Central Nervous System- Inflammation in Aged Mice
… Collectively, it is evident that systemic inflammation is a contributing factor for the development of infection and sepsis.</p> <p>In conclusion, social isolation exacerbates stroke outcomes, and alters microRNA expression profiles, suggesting a potential interplay between social factors, …