Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"peripheral T cells"”.
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Recent Thymic Emigrants and their Biomarkers
The main development of T cells takes place in the thymus. However, T cells that have just exited the thymus, called Recent Thymic Emigrants, are not yet fully matured and thus have different characteristics and functionalities than mature peripheral T cells. Several biomarkers exist for these …
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Effects of Thymus Size and Involution On The Contribution of Recent Thymic Emigrants to The Peripheral T Cell Pool
… of recent thymic emigrants (RTEs) to the peripheral naïve T cell population is necessary to maintain diversity of the T cell receptor (TCR) repertoire and produce immune responses against newly encountered antigens.</p> <p>The thymus involutes with age, after irradiation or chemotherapy, …
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Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
… perpetual release of self-MHC restricted naive T cells. However, thymus involution during the aging process reduces naïve T cell output, leading to defective immune responsiveness to newly encountered antigens. We have found that early thymus involution precipitates the age-associated shift …
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The roles of clustered membrane proteins in T-cell signaling
… that can respond to diverse pathogens. Mature T cells, one of the most important immune cells generated from the thymus through a rigorous selection processes, are key orchestrators of the immune responses. Although many of the key signaling molecules in T cells have been discovered, the …
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Defining the Role of CD3 Zeta ITAMs in T Cell Signaling and Development
Alpha beta T cells express a T cell receptor (TCR) composed of an alpha beta heterodimer that is responsible for ligand recognition, which is associated with six invariant signaling chains, termed the CD3 subunits. These are organized into two independent signaling modules, the CD3 gamma epsilon / …
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Identification and analysis of Il-2 induced Stat5 Target genes in Human CD4 and CD8 T cells
… and activated primary human CD4 and CD8<br/>peripheral T cells.<br/>Six libraries were generated, which identified 329 STAT5a and/or STAT5b-specific<br/>binding sites of which 87% contained canonical GAS motifs, TTCN3GAA and/or<br/>TTN5AA. Genomic mapping of sites revealed the striking …
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The Function of LAT in T Cell Activation and Autoimmunity
<p>LAT (linker for activation of T cells) is an important transmembrane adaptor protein in TCR-mediated signaling. Upon TCR engagement, LAT associates with multiple proteins which allows for the activation of downstream signaling pathways. The interaction between LAT with phospholipase C …
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The Influence of the Microbiota on T Cell Development
… distinct phenotypes compared to mature naïve T cells (MNTs), including being more prone to differentiate into peripherally induced regulatory T cells, which makes the cells interesting in the context of things such as autoimmunity. Previous research has suggested that the microbiota, …
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Costimulatory function of CD44
… Cross-linking of CD44 induces proliferation of peripheral T cells and apoptosis of thymocytes and a T helper line in the presence of subthreshold levels of anti-CD3. CD44-induced proliferation was accompanied by an upregulation of the activation markers CD25 and CD69 and an increased cytokine …
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Immunological mechanisms controlling chronic inflammatory diseases
… diseases (CID) mediated by self-reactive T and B cells and are generally the results of the breakdown of T cell tolerance to self-antigen and failure of peripheral regulatory mechanisms. In this thesis I studied different mechanisms controlling the development of CIDs. I investigated the initial …
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Targeting TNFSF10 as a novel immunotherapeutic strategy in Alzheimer’s disease
… could imply a re-balance of both central and peripheral immune response and whether this could relate to the decreased Aβ burden in the brain of 3xTg-AD mice, a transgenic strain resembling human AD pathology and already known to display improvement of functional outcome following treatment …
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Genetic Loci Contributing to Spontaneous Autoimmune Diabetes
… organ as well as in FACS sorted thymocytes and peripheral T-cells stained with CD4 and CD8 monoclonal antibodies showed a reduction in expression of four out of five Gimap genes located within the Iddm39 interval, in addition to Gimap5, in DR.lyp/lyp spleen and mesenteric lymph nodes (MLN) when …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… roles. In response to foreign antigens, naïve T cells activate expand and differentiate into effector T cells which mediate pathogen elimination. During the aftermath of pathogen clearance, a subset of effector T cells revert back to quiescence and differentiate into memory T cells. The Forkhead …
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The dependence of CD4 T cell development and activation on the kinetics of the TCR:pMHC interaction
… player in the adaptive immune response. T cells function by stimulating antibody production by B cells, secreting cytokines to attract other immune cells, regulating the response of other T cells, and directly killing infected or damaged targets. The role of the adaptive immune response …
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Isolation And Characterisation Of Immunoglobulin Gene Superfamily Molecules From Lower Vertebrates (Fish)
… and present self and foreign peptides to T-cells via the TCR, causing the T cell to proliferate and secrete cytokines. There is increasing evidence that peripheral T cells and MHC restricted cellular immune responses occur in all vertebrates. However, the exact nature of the TCR and MHC in …
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Engineering and characterizing human T cell receptors for cancer immunotherapies
… tolerance leads to the deletion of T cells with TCRs against possible cancer peptide self- antigens. Those TCRs that remain typically do not have the required affinity to mediate a sufficient T cell response. To overcome this, TCRs can be engineered for higher- affinity ex vivo and …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening of lymphocyte subsets in splenocytes and in peripheral blood. Genetic mapping and sequencing identified the two mutations. The first was a …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening of lymphocyte subsets in splenocytes and in peripheral blood. Genetic mapping and sequencing identified the two mutations. The first was a …