Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"perinnöllisyystiede"”.
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Genetic aspects of outcome in kidney transplantation : cytokine and thrombosis associated candidate genes and gene expression biomarkers
Kidney transplantation (Tx) is the treatment of choice for end stage renal disease. Immunosuppressive medications are given to prevent an immunological rejection of the transplant. However, immunosuppressive drugs increase e.g. the risk of infection, cancer or nephrotoxicity. A major genetic …
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Recognizing Lynch Syndrome by DNA Mismatch Repair Deficiency
The most common inherited cancer syndrome, Lynch syndrome (LS), is caused by a defected post-replicative DNA mismatch repair (MMR) pathway. Human MMR is initiated by the binding of a heterodimeric mismatch recognition factor MutSα (MSH2+MSH6) or MutSβ (MSH2+MSH3), followed by the assembly of the …