Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"pericyte"”.
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Pericyte deficiencies in a foxf2 loss of function mutant
Pericytes are critical players in vascular development and disease but are not widely studied in the context of cerebral small vessel disease, a vascular condition related to stroke that progressively weakens brain microvessels. Foxf2, a pericyte-expressed gene, is involved in vascular stability …
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PERICYTE SUBTYPES AT THE INTERSECTION BETWEEN TISSUE REGENERATION AND PATHOLOGY
… and can lead to organ failure. Cells called pericytes, located around blood vessels, act as stem cells. Some studies suggest that pericytes may contribute to regeneration in various organs as well as fibrous tissue and fat formation in response to aging and pathologies. Based on markers and …
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Notch deficiency leads to arteriovenous malformations and altered pericyte function
… sprout from pre-existing vasculature and recruit pericytes to induce maturation and vessel quiescence. Perictyes are associated with small vessels and capillaries where they share the basement membrane with the endothelium to provide vascular support. Pericytes are a critical component of the …
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Skeletal muscle pericyte response to acute and chronic electrical stimulation
Pericytes are mural cells that are located on the outer surface of blood capillaries where they attach to endothelial cells and regulate vascular function, including dilation and angiogenesis. Recent studies suggest that pericytes in skeletal muscle may contribute to myofiber repair in response to …
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The Effect of Ischemia and High-Fat Diet on Pericyte Fate
… fat (HF) diet and ischemia on skeletal muscle pericytes. Pericytes are mural cells on the abluminal surface of capillaries that contribute to capillary stabilization and the regulation of angiogenesis, but their roles in the events that occur during muscle recovery from ischemia in patients …
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Extracellular Matrix Contributions to Early Vascular Development and Pericyte Precursor Dynamics
… level, specifically endothelial cells and pericytes as well as the surrounding protein microenvironment, known as the extracellular matrix (ECM). Impaired coordination amongst the cellular and protein constituents results in the improper functioning of the vascular network and can …
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Biophysical Influence of Nanofiber Networks to Direct Pericyte Aggregation into Spheroids
… spatially pattern spheroids comprised of human pericytes. We show that fiber architecture (aligned vs. crosshatched), diameter (200, 500, and 800 nm), and contractility influence spheroids in their spontaneous formation, growth, and maintenance, and report a dynamic trade of cells between …
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Optimization of a pericyte therapy to improve muscle recovery following hindlimb immobilization
… disease). Our lab recently demonstrated that pericyte quantity is decreased in skeletal muscle following immobilization and appropriate replacement via intramuscular transplantation can effectively recover myofiber size in mice. These data suggest that pericytes positively influence skeletal …
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Pericyte-Endothelial Cell Interactions during Blood Vessel Formation and in Diabetic Scenarios
… Specialized vascular cells known as pericytes (PCs) are lost or become dysfunctional during disease progression; a thickening of the extracellular matrix (ECM) composing the vascular basement membrane (vBM) and endothelial cell (EC) tight junction disruption are also key features of …
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Development of a pericyte-based strategy to recover aged skeletal muscle after disuse
… perivascular stem cells (NG2+ and CD146+ pericytes), also considered the primary mesenchymal stem cell (MSC) in muscle, can effectively recover muscle mass in young adult mice following a period of immobilization. However, several questions remained after the completion of this study. What …
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Pericyte and Endothelial Cell Responses within Murine Cerebral Capillaries After Blood Flow Cessation
… of the microcirculation is the vascular pericyte (PC), which is essential for angiogenesis and the regulation of microvascular biomechanics. This thesis focuses on the cerebrovascular network, particularly the cerebral microcirculation, and investigates the role of pericytes in …
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Development of a pericyte-derived extracellular vesicle therapy for the recovery of skeletal muscle mass following immobilization
… capacity reside in skeletal muscle, including pericytes and fibroblasts, yet minimal information exists regarding their response to exercise and their subsequent contribution to muscle growth. Thus, the purpose of this study was to characterize the perivascular stem/stromal cell response to …
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Development of a stem cell-based therapy for the recovery of skeletal muscle mass following immobilization
… Perivascular stem/stromal cells, including pericytes, reside in close proximity to microvessels, possess myogenic capacity, and secrete various regenerative paracrine factors, making them ideal candidates for stem cell-based therapies. However, minimal information exists regarding their …
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The impact of diet-induced obesity and exercise on adipose-resident stem cells
… as adipose-derived stromal cells, or ADSCs) and pericytes may secrete factors such as collagen and metalloproteinases that can allow for tissue turnover. Therefore, the primary goal of this dissertation was to examine the impact of long-term high fat feeding on vascular-associated stem/stromal …
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Delta Like Ligand 4 Is A Critical Regulator of Bone Marrow Cell Differentiation Into Pericytes/Vascular Smooth Muscle Cells and Is Essential For The Vasculogenesis That Supports The Growth of Ewing’S Sarcoma
… that these bone marrow cells differentiate into pericytes/vascular smooth muscle cells(vSMC) and contribute to the formation of the functional vascular network. The molecular mechanisms that control bone marrow cell differentiation into pericytes/vSMC in Ewing’s sarcoma are poorly understood. …
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Adult Neural Stem Cells and Their Perivascular Niche
… vessels at sites that lack glial end feet and pericyte coverage, a feature unique to SVZ vasculature. Diffusible signals from transformed endothelial cell lines have been shown to increase survival, proliferation and neurogenic differentiation of SVZ neural stem cells and their progeny in …
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ELUCIDATION OF THE UNIQUE TRANSLATION OF ANGIOGENIC SIGNALING BY AORTIC VALVE CELLS
… VECs translate angiogenic signals. Next, the pericyte-like capacity of VICs was demonstrated by tracking fluorescently marked VECs and VICs in a long term in vitro angiogenesis co-culture assay. VICs regulated early VEC network organization in a ROCK-dependent manner, wrapping themselves …
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Stem cell based therapy of malignant brain tumors
… into tumor blood vessel walls and expressed pericyte markers but not endothelial cell markers. The pericyte marker expression profile and perivascular location of implanted MSCs indicate that these cells act as pericytes within tumors. MSC implantation did not, however, affect tumor …
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Effect of the Pdgfbʳᵉᵗ mutation on cardiovascular homeostasis
… and disease. During angiogenesis PDGFB regulates pericyte migration and proliferation during development and in tissue repair. Pericytes confer vessel stability, maintain vessel integrity, and control vascular tone. In the field of regenerative medicine, pericytes have also risen to prominence as …
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Insulin Resistance and Inflammation in Neurodegeneration: Lessons from in vitro Models
… of IR and chronic inflammation in neurons and pericytes that line the BBB. A chronic insulin model of insulin resistance in differentiated human neurons was developed to examine changes in gene expression associated with an insulin resistant state. Microarray analysis revealed altered …
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