Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"pericarditis"”.
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Studies of effusive constrictive pericarditis
Tuberculous (TB) pericarditis is associated with a mortality rate of 17-40% despite treatment with anti-tuberculosis drugs. The complications of TB pericarditis that confer mortality and morbidity are pericardial tamponade, effusive constrictive pericarditis, and constrictive pericarditis. Whilst …
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The initiative to investigate the management of Pericarditis in Africa (IMPI) Registry : a substudy on the causes of constrictive pericarditis and predictors of mortality in patients with constrictive pericarditis requiring pericardiectomy at Groote Schuur Hospital (The Constrictive Pericarditis Substudy)
Background: Causes of constrictive pericarditis and predictors of peri-operative outcome following pericardiectomy are not clearly elucidated, especially in Africa, where disease characteristics differ from developed countries. Furthermore, the impact of HIV/AIDS on pericardial constriction and …
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Development of a risk score for constrictive pericarditis using the Investigation of the Management of Pericarditis randomised clinical trial dataset
… decline of tuberculosis infections, constrictive pericarditis, one of the most serious consequences of tuberculous pericarditis, continues to be a major cause of morbidity and mortality in sub-Saharan Africa. Currently, while the risk of constrictive pericarditis in individuals with tuberculous …
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Investigating the pathways involved in the progression of fibrosis in tuberculous pericarditis
… cases of tuberculosis (TB) globally. Tuberculous pericarditis (TBP) is a severe form of EPTB involving the pericardium that is present in 1-2% of TB cases, and poses diagnostic and therapeutic challenges, with mortality rates ranging between 8-34% despite anti- tuberculous therapy. TBP is the …
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An examination of the post mortem records of 500 cases pericarditis in children
… of the Post Mortem records of cases of Pericarditis at the Hospital for Sick Children, Great Ormond Street, London. The original intention was to examine the cases of Pyopericardium only, but I have thought it better to give an account of all the cases in the records in which the …
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The tetrapeptide Ac-SDKP and angiotensin converting enzyme in tuberculous pericarditis and fibrosis
Tuberculous pericarditis is an extra pulmonary form of tuberculosis (TB) which leads to a lifethreatening form of pericardial fibrosis in up to 25% of patients despite anti tuberculous therapy. The mechanisms leading to the fibrotic phenotype following infection are poorly understood. A proof of …
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Investigation of the management of tuberculous pericarditis (IMPI) registry : survival and outcomes sub-study
Includes abstract. Includes bibliographical references.
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The prevalence, determinants, natural history and impact of atrial fibrillation and atrial flutter in patients with tuberculosis pericarditis - insights from the IMPI trial
Tuberculosis is the most common cause of pericarditis in Africa. The dual human immunodeficiency virus (HIV)-tuberculosis epidemics are major contributors to the burden of extra-pulmonary tuberculosis, including tuberculous pericarditis. Mortality rates remain unacceptably high. Atrial fibrillation …
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A description of the pharmacokinetics of first line anti-tuberculosis drugs and adjunctive corticosteroid therapy in the pericardial compartment and their effect on cytokine profiles in the pericardial compartment of patients with tuberculous pericarditis
Tuberculous pericarditis is caused by Mycobacterium tuberculosis infection of the pericardium, which is associated with a higher mortality, compared with pulmonary tuberculosis. Constrictive pericarditis, a significant complication of tuberculous pericarditis, contributes to this elevated …
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Exosome Prevention of Post Operative Atrial Fibrillation
… undergo sham operation or induction of sterile pericarditis followed by trans-epicardial injection of human EVs or vehicle into the atrial tissue. Pericarditis increased the probability of inducing AF while EV treatment abrogated this effect in a sex independent manner. EV treatment reduced …
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Cardiology Implications of ED COVID-19 Patients in an Underserved Rural Health Care Environment
… complications (e.g., STEMI, NSTEMI, myocarditis, pericarditis, AF) specifically among underserved communities. Acute STEMI and NSTEMI are cardiac conditions associated with ruptured atherosclerotic plaque leading to significant myocardial injury. AF, the most common arrhythmia leading to …
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The effects of angiotensin converting enzyme inhibitors (ACEI) on human N-acetylseryl-aspartyl-lysyl-proline (AcSDKP) levels : a systematic review
… condition that is complicated by constrictive pericarditis in 4-8% of cases. N-acetyl-seryl-aspartyl-lysylproline (Ac-SDKP) is a ubiquitous tetrapeptide with antifibrotic properties that is low in tuberculous pericardial effusion, thus providing a potential mechanism for the heightened fibrotic …
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Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection
Background:Tuberculous pericarditis includes the spectrum of pericarditis caused by Mycobacterium tuberculosis manifesting with pericardial effusion, cardiac tamponade, effusive-constrictive and constrictive pericarditis. In patients with pericardial tuberculosis, co-infection with human …
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Mapping the Characteristics of Atrial Activation Patterns During Atrial Fibrillation
… (512 recording sites) in the canine sterile pericarditis model and in AF patients. Studies of AF in the canine sterile pericarditis model have demonstrated that AF is due to one or more driver sites firing rapidly causing fibrillatory conduction. The ability to reliably identify such driver …
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The transciptomic landscape of HIV-TB
… in blood and the site of disease in tuberculous pericarditis. The final chapter in this part describes the methods used to generate and analyse the systems-level data, with emphasis on microarray data generation and analysis. Part 2 first presents analysis of transcriptional data generated by …
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The diagnostic value of pericardial aspiration at Groote Schuur hospital
… clinically assessed as having tuberculous pericarditis) is noted, and recommendations to improve the yield from culture are made.
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Cardiotoxicity In Hematologic Stem Cell Transplant: Keeping The Beat
… arrhythmia, pericardial effusion, and pericarditis. Our multivariable regression analysis identified age (older), creatinine (higher) and history of coronary artery disease to significantly correlate with risk of cardiac event (p = 0.005, p = 0.039, p = 0.038 respectively). Patients …
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Diagnostics for joint models for longitudinal and survival data
… set from a multi-center clinical trial on TB pericarditis (IMPI). The second contribution was to implement a variance shift outlier model (VSOM) in the two-stage joint survival model. This was achieved by identifying outlying subjects in the longitudinal sub-model and down-weighting before the …
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