Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"periaqueductal gray"”.
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The role of the periaqueductal gray in modulation of acute and chronic pain: Actions of drugs with analgesic properties on periaqueductal gray neuronal network
… suggests the involvement of the ventrolateral periaqueductal gray (PAG) in both inhibitory and facilitatory actions within modulatory pathways for pain, The PAG is a critical nucleus in these pain networks and receives and sends extensive projections within these networks. Chronic pain is a …
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Electrical stimulation of the ventral lateral periaqueductal gray induces antinociception in rats
… in the brain and the central nervous system, the periaqueductal gray (PAG) has been shown to be a key site that modulates antinociception responses. We hypothesize that electrical stimulation of the ventral lateral periaqueductal gray (vIPAG) in rodents reliably induces antinociception in a …
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Cyclodextrins as a suitable carrier for the induction of feeding and analgesia by Delta-9 THC: a preclinical study in the female rat
… in pain- and reward-related brain regions (periaqueductal gray, ventral tegmental area, nucleus accumbens, and prefrontal cortex). Additionally, hepatic concentrations of THC, its principal metabolites (11-OH-THC and 11-COOH-THC), and fatty acid metabolic markers were measured to evaluate …
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Study of the Role of the Bed Nucleus of the Stria Termialis D1- and D2-Like Dopamine Receptors in Cocaine Self-Administering Rats
… shell (NAc shell), retrorubral nucleus (RR), periaqueductal gray region (PAG)), BST dopamine receptors are indeed an important part of the highly integrated reward system and thus possess sensitivity to pharmacological rewards. In the present study, the effects of bilateral intracranial …
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Dopaminergic modulation of prefrontal cortex subpopulations
… ratio in mPFC neurons projecting to the dorsal periaqueductal gray (dPAG) during the processing of an aversive stimulus. First, using electrochemical approaches, we reveal the precise time course of tail pinch-evoked dopamine release in the mPFC. Second, we show that dopamine signaling in the …
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Sex-dependent and Sex-independent Gene Regulation after Peripheral Nerve Injury
… sex differences in the spinal cord, periaqueductal gray (PAG), and blood of animals without nerve injury. I found that PNI changes the DNA methylation landscape in a sex-specific manner in all three tissues. I discovered that PNI resulted in genome-wide hypermethylation throughout the …
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Neuroplastic Adaptations to Exercise Training and Detraining
… areas were examined in coronal sections: the periaqueductal gray (PAG), posterior hypothalamic area (PH), nucleus of the tractus solitarius (NTS), rostral ventrolateral medulla, cuneiform nucleus (CnF), nucleus cuneatus and cerebral cortex. Neurons were traced using a camera lucida technique …
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A midbrain mechanism for computing escape decisions in the mouse
… while VGluT2 neurons of the dorsolateral periaqueductal gray (dPAG) are silent until just before the initiation of escape, and are maximally active during escape. These results suggest that the dmSC accumulates evidence of threat which dPAG neurons threshold. This interpretation is …
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Molecular Substrates And Neuronal Network Subserving Audiogenic Kindling In Genetically Epilepsy-Prone Rats
… which in turn has major projections to the periaqueductal gray (PAG). Previous studies have demonstrated the existence of projections from the CeA to the ventrolateral nucleus of periaqueductal gray (PAG). In GEPR-9s, the PAG, is known to play a critical role in the propagation of AGS. …
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Investigation of somatomotor-sympathetic brain circuit abnormalities in two rat models featuring inborn differences in emotional behavior
… nucleus (PVN), locus coeruleus (LC), and periaqueductal gray (PAG), are implicated in responses to stressful and emotionally salient stimuli. Based on this observation, it was hypothesized that these parallel descending circuits shape responses to diverse stressors and are altered in …
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ONTOGENY AND NEURAL MECHANISMS OF VOCAL COMMUNICATION IN MUS MUSCULUS
… including adult mouse social USVs - the midbrain periaqueductal gray (PAG). In Study 4a, I begin testing the hypothesis that the same PAG neurons regulate USV production across development, in both pups and adults. I use immunohistochemistry to detect expression of Fos, a marker for recent neural …
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The development and plasticity of visuo-spatial orienting behaviors and underlying circuitry in adolescent mice
Sex differences in visual processing during behavior exist across a wide variety of species, from flies to humans. However, it remains unclear whether sexual dimorphism in natural visual behavior exists for standard laboratory strains of mice, a prominent model for understanding the neural basis of …
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NEUROACTIVE AGENTS-MEDIATED CHANGES IN NEURONAL NETWORK ACTIVITY CONTROLS SUSCEPTIBILITY TO SUDDEN UNEXPECTED DEATH IN EPILEPSY (SUDEP)
… human SUDEP imaging has underlined the role of periaqueductal gray (PAG), which is also implicated in audiogenic seizure (AGSz) network and respiratory modulation in other models. The goal of my dissertation is to understand the mechanisms by which adenosine could cause SUDEP susceptibility, the …