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Showing 1 to 5 of 5 for “"peptidoglycan hydrolase"”.
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Structural and Functional Studies of Sensor Kinase RetS from Pseudomonas aeruginosa and Peptidoglycan Hydrolase SleB from Bacillus anthracis
… enzymes (GSLEs) that degrade the unique cortex peptidoglycan to permit resumption of metabolic activity and outgrowth. We report the first crystal structure of the catalytic domain of a GSLE, SleB. The structure revealed a transglycosylase fold with unique active site topology and permitted …
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Evaluating The Impact of Post-Translational Modifications By The Secreted Zinc Metalloprotease, Gele, On The Major Autolysin of E. Faecalis, Atla, and A Stress-Induced Protein, Salb
<p>AtlA is the major peptidoglycan hydrolase of <em>E. faecalis</em> involved in cell separation of dividing cells. SalB is a secreted stress-induced protein regulated by the CroRS system. In addition, these two proteins also appear to be affected by the virulence factor, gelatinase (GelE). GelE is …
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Characterization of a bifunctional cell wall hydrolase in the mobile genetic element ICEBsJ
… Most, if not all ICEs encode an enzyme with peptidoglycan hydrolase function that is involved in transfer. While these hydrolases are widespread, they are some of the least-studied components of conjugative transfer systems, and very little is known about their function. The integrative and …
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Biochemical Studies of Peptidoglycan Hydrolases from Commensal and Pathogenic Bacteria
… human health. Interestingly, cell wall, or peptidoglycan, fragments from commensal and pathogenic bacteria can activate host immunity. The mechanism(s) by which immunologically active peptidoglycan fragments are generated, however, are not well-understood. In this regard, peptidoglycan …
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Characterization of Bacterial Metabolites Involved in Host Pathogen Resistance
… proteomic approaches, we identified a secreted peptidoglycan hydrolase (SagA) from E. faecium that confers protection against Salmonella pathogenesis. Our results indicate that SagA does not directly inhibit pathogen growth, but instead remodels peptidoglycan in vivo to enhance host resistance …