Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"peptide-MHC complexes"”.
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In silico prediction of C57BL/6 mouse T-cell epitopes: enhancing immunogenicity assessment with PREDBL6
The MHC class I antigen processing pathway involves multiple steps: 1) the proteasome selectively cleaves intracellular proteins into short peptides, typically 8–11 amino acids long; 2) TAPs (transporter associated with antigen processing) selectively transport some of these peptides to the …
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Expanding Antigen-specific Tr1 Cells to Treat Autoimmunity
… therapy which consists of disease-relevant peptide-MHC complexes coated on iron-oxide nanoparticles (NPs). We have demonstrated that the therapeutic effects exerted by these NPs are associated with expansion of antigen-specific T-regulatory-type-1 (Tr1) cells and immuno-suppression of …
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Engineering Proteins Encoded by the Major Histocompatability Complex
… encoded by the major histocompatability complex (MHC) were initially discovered based on their role in skin graft rejections. Years later, the physiological function of MHC proteins, as key players in the immune response to foreign pathogens, was elucidated. For instance, class I major …
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Elucidating the functional states of tumor-resident dendritic cells that drive productive anti-tumor immunity
… by crossdressing with pre-formed tumor-derived peptide-MHC complexes. We determined that constitutive tumor cell-derived type-I-interferon (IFN-I) production in regressor tumors was driving the ISG+ DC state. Ablation of tumor cell-derived IFN-I in regressor tumors led to complete loss of …
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Stochastic and spatiotemporal effects in T-cell signaling
… interaction between T cell receptors (TCR) and peptide-MHC complexes (pMHC), the second on the equilibrium affinity (KD). We study an extensive set of TCR-pMHC interactions in CD4+ T cells which have differential KD and kinetics of binding. The data indicate that ligands with short t1/2 can be …
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Novel peptide antigens provide insights into the recognition process by T cells
… the reactivity of T cell receptors with novel peptide antigens. The first study (Chapter 2) described a collection of novel peptide antigens for a single T cell receptor and their diverse requirements for the co-receptor CD8. One of the peptides showed no activity despite binding the TCR, and …
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Recognition of hepatitis B epitopes by T cell receptors and T cell receptor-like antibodies
… αβ T cell receptor (TCR). The TCR recognizes a peptide epitope presented by a product of the major histocompatibility complex (MHC). All nucleated cells express class I MHC products, typically in association with one of thousands of “self” peptides. However, during a viral infection, “foreign” …
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THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY
… IL-2, CD80 and CD40L singnaling, and weaker peptideMHC I (pMHC) signaling, Th-APCs stimulated naïve CD8+ T cells to differentiate into effector CTLs, capable of developing into, central memory CTLs. Th-APC-stimulated CD4+ T cells behaved like Th cells in function, augmenting the overall …