Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"peptide vaccines"”.
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Structure-guided Cancer Vaccines based on Glycopeptides Supported on Diverse Nanoparticles
… strategy is that of therapeutic cancer vaccines, which can use tumor-associated peptide fragments that can induce an immune response. In this thesis, we focus on the peptide sequence of MUC1, a glycoprotein presents on the surface of epithelial cells, which leaves simple carbohydrates, …
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Interpretations of Machine Learning and Their Application to Therapeutic Design
… framework for the computational design of robust peptide vaccines. Our framework optimizes the n-times coverage of each individual in the population to activate broader T cell immune responses, account for differences in peptide immunogenicity across individuals, and reduce the chance of vaccine …
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Immunological control of toxoplasma gondii infection
… and encephalitis. Currently there are no human vaccines available. The first major aim of this study was to test potential HLA restricted peptide vaccines, previously shown to be protective in HLA-transgenic mice, against oocyst infection. The ability of entrapment within non-ionic surfactant …
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Tapasin - The star of the show in HLA-I maturation
… of all nucleated cells. They bind intracellular peptides and present them to the immune system thus providing a readout to cytotoxic T-cells about the status of a cell. Maturation of the HLA-I molecule includes peptide binding in the endoplasmic reticulum with the assistance of several other …
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A Novel Platform to Generate Synthetic Vaccine Candidates
… there remain viruses against which no effective vaccines exists including human immunodeficiency virus (HIV), West Nile Virus (WNV) and hepatitis C virus (HCV). These viruses and others evade the immune response by undergoing rapid mutations in immunodominant epitopes [4-6]. In addition, although …
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Synthesis of mannosylated peptides as components for synthetic vaccines
… cells and infectious agents from the unique peptides found on their surfaces therefore, synthetic peptides of similar structure can be used as vaccines to stimulate the immune system. Despite the problems associated with proteolysis and delivery to the immune system, peptide-based vaccines …