Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"peptide therapeutics"”.
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DE NOVO DESIGN OF ANTIMICROBIAL PEPTIDES FOR APPLICATION AS ANTI-INFECTIVE AGENTS
Antimicrobial peptides (AMPs) have gathered considerable interest as a new source of antibiotics to tackle the escalating threat of antimicrobial resistance. Adopting a de novo approach enables the rational design of short synthetic AMPs, whilst mitigating concerns of resistance development to …
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The development of stapled peptides as chemical tools to investigate activin A signalling and as antibacterial agents targeting MsbA-mediated efflux
Peptides are recognised for their ability to disrupt protein-protein interactions (PPIs), which have traditionally been considered ‘undruggable’ with small molecules. However, due to issues such as a susceptibility to degradation by proteases, the use of peptide therapeutics in the clinic has been …
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Studies of the Physical Stability of GLP-1 & Chemically Modified Forms of GLP-1
Biopharmaceuticals, including proteins and peptides, are becoming increasingly important as therapeutic agents. However, the clinical use of protein and peptide therapeutics is still restricted due to undesirable properties such as their ability to self-assemble and aggregate. These properties not …
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Design of oral insulin tablet formulations to enable manufacture and storage under ambient conditions
The development of oral peptide therapeutics is significantly limited by poor gastrointestinal bioavailability and instability during manufacturing and storage. Insulin, a peptide prone to enzymatic degradation, aggregation, and chemical modification, serves as an exemplary model for addressing …
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The synthesis of bimane constrained peptides and their fluorescent and structural properties
… protein-protein interactions however constrained peptides, have shown to have great therapeutic potential. Short peptides display little secondary structure in aqueous solution and as such, peptide sequences derived from a protein-protein interaction interface for use as a protein-protein …
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Structural investigation of lanthipeptides involved in substrate controlled pathways and methods for leader peptide removal
… synthesized and post-translationally modified peptides are a family of natural products with diverse activities, with lanthipeptides as one of the most prominent classes. The diverse ring topology of lanthipeptides is formed by four classes of enzymes with substrate tolerance that holds …
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Towards Inhibition of Oncogenic RhoA Signaling using Stapled Peptides
… including the Ras superfamily of small GTPases. Peptide therapeutics are emerging as promising new modalities to more efficiently inhibit these "undruggable" targets. RhoA is a member of the Rho family within the Ras superfamily of small GTPases and is a major regulator of cytoskeletal …
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Investigating the Structure and Physical Stability of Glp1-Like Peptides Using Mass Spectrometry
Working with fibrillation prone peptides is an adventure, to say the least, but harnessing their therapeutic potential is a challenge worth facing. On comparison to small molecules, peptides provide improved efficacy coupled with reduced toxicity; the difficulty lies in their pharmaceutical …
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Evaluation of the oral delivery of goserelin with Pheroid® technology
The therapeutic amphiphilic peptide, goserelin, being investigated in these studies, is a type of hormone therapy generally used in addition to standard adjuvant therapy. Goserelin serves as treatment for numerous hormone-dependent disorders, for instance benign conditions (e.g. uterine fibroids, …
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The Voltage Gated Sodium Channel β1/β1B subunits: Emerging Therapeutic Targets in the Heart
… of and treatment with an SCN1B Ig domain mimetic peptide βadp1. Here we describe further investigation into the function and mode-of-action of both βadp1 and novel peptides derived from the original βadp1 sequence. We find that in a heterologous expression system βadp1 initially disrupts …
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Polysequence Nanomaterials for Immunomodulation
<p>Peptide-based vaccines have received growing interest due to their specificity and ability to limit off-target effects, and they are currently being explored toward a variety of infectious diseases and therapeutic targets. However, the efficacy and applicability of such epitope-based vaccines …
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Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System
<p>Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System by Jonathan A. Moreno Peptides</p> <p>[RW]<sub>4</sub> and [R<sub>5</sub>W<sub>4</sub>] have been previously identified as molecular transporter Cell Penetrating Peptide (CPP) and antimicrobial agents, respectively. These …
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Studies on the physical stability of a C-terminally amidated variant of GLP-1
The phenomenon of peptide and protein aggregation is of great biochemical importance. Not only is it a key feature of numerous neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease, but it also plays a significant role in the manufacturing and processing of therapeutic …