Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"peptide stability"”.
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Towards an understanding of peptide-inorganic interactions
… principles through which interactions at peptide-inorganic interfaces occur. The inorganic materials; crystalline zinc oxide (ZnO) and platinum (Pt) together with specific binding peptides identified using the phage display technique and alanine scanning for mutant sequences selected on …
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Specificity of Interaction of Antimicrobial Peptide with Cell Membrane
… low toxicity to combat this issue. Antimicrobial peptides (AMPs) represent a promising solution. These peptides exhibit broad-spectrum antimicrobial activity and rapid killing kinetics, reducing the likelihood of resistance development. AMPs primarily target bacterial cell membranes. Their …
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Engineering Proteins Encoded by the Major Histocompatability Complex
… by binding and ""presenting"" antigenic peptides from bacteria, viruses or parasites. A class I MHC protein consists of a heavy chain (45 kDa) with three domains (alpha1alpha 2alpha3) and a light chain called beta2-microglobulin (12 kDa) that associates with the alpha3 domain. Peptides …
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Biosynthesis of the antimicrobial peptide epilancin 15X
Lantibiotics are polycyclic antimicrobial peptides that are ribosomally synthesized and posttranslationally modified to their biologically active forms. The recently discovered lantibiotic epilancin 15X produced by Staphylococcus epidermidis 15X154 is active against several pathogenic bacteria, …
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An investigation into the aggregation of therapeutic peptides through adsorption to primary containers
Therapeutic peptides are highly functional drugs currently being investigated for a number of diseases, due to their naturally occurrence in the body, their targeted mechanism and efficacy and tolerability. The four therapeutic peptides under investigation in this thesis; glucagon, liraglutide, …
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The Discovery and Chemical Synthesis of Peptides and Proteins that Cross Biological Barriers
… cells remains a complex task. Cell-penetrating peptides (CPPs) and proteins are used as carrier modules, tissue targeting agents, and probes to better understand disease states. In this work, we first investigate CPPs for peptide-mediated delivery of macromolecules. Despite the existence of …
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Studies on the physical stability of a C-terminally amidated variant of GLP-1
The phenomenon of peptide and protein aggregation is of great biochemical importance. Not only is it a key feature of numerous neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease, but it also plays a significant role in the manufacturing and processing of therapeutic …