Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"peptide production"”.
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Chlorinated amino acids in peptide production
A new method for the production of peptides through biological expression was developed, utilising lactonisation-prone chlorinated amino acids for latent peptide bond digestion. Incorporation of halogenated amino acids into proteins is possible due to the inherent inability of the biological …
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Chlorinated amino acids in peptide production
A new method for the production of peptides through biological expression was developed, utilising lactonisation-prone chlorinated amino acids for latent peptide bond digestion. Incorporation of halogenated amino acids into proteins is possible due to the inherent inability of the biological …
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Gene expression control and antimicrobial peptide production by haute couture bacteria
… to inducibly express and secrete antimicrobial peptides with activity against Escherichia coli and Salmonella typhimurium and infantis. This is the first demonstration of bacteria engineered to inducibly produce peptides with strong activity against Gram-negative pathogens. These systems may …
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Analysis of peptide production by Lactobacillus species and evaluation of their antihypertensive and immunomodulatory activities
… process which liberate small bioactive peptides from larger milk proteins (eg. casein). We observed that supplementation with 0.1% casein significantly increased the growth rate of L. helveticus R0389 and L. rhamnosus R0011 and increased the ACE-inhibitory activity of their secreted …
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Systems Immunology Approaches for Precision Medicine
… of the hypothesis that host-antimicrobial peptide production may correlate with increased disease severity and promote increased recurrence. Secondly, it provides insight into the necessity of trans-disciplinary analysis for the understanding of novel molecular targets in disease through …
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Investigation of the production and isolation of bioactive compounds from cyanobacteria.
… nodularins (NOD) and a range of other bioactive peptides such as spumigins and nodulopeptins, all of which have unclear function. In a recent study, three new nodulopeptins with molecular weight of 899, 901 and 917 were characterised from N. spumigena KAC 66. In the present study, N. spumigena …
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APP Processing: A Biochemical Competition Influenced by Exercise-Induced Signalling Mediators
… is excessive accumulation of amyloid-β (Aβ) peptides, which can aggregate to form the plaques commonly associated with this disease. These plaques are often observed well before symptoms of AD develop. Therefore, it is important to find ways to regulate the pathways involved in the production …
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Novel Mechanisms of Antigen Processing That Enhance Bcg Vaccine Efficacy
… Since lysosome fusion is necessary for peptide production and T cell priming leading to protective T<sub>H</sub>1 immunity, we hypothesized that vaccine efficacy is reduced and occurs perhaps due to non-lysosome dependent mechanisms. We therefore proposed an in depth analysis of …
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Heterologous production of recombinant peptidylglycine α-amidating monooxygenase for the production of biosimilar α-amidated peptides
A biological method for peptide synthesis provides increased production capacity of inexpensive peptide pharmaceuticals with environmentally safe procedures relative to current chemical peptide synthesis. Most precursor peptides are readily produced from yeast and bacterial systems using …
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The effects of low-shear modeled microgravity on Streptococcus pneumoniae and adherent-invasive Escherichia coli
… involved in competence induction, antimicrobial peptide production, and carbohydrate uptake. \r\nWhile previous studies examining the effects of LSMMG on bacteria have focused on well-characterized strains of both commensal and pathogenic species, there is limited information regarding the …
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Factors That Mediate Expression Of Unique Ggggcc Repeat Expansions In C9orf72-Associated Als/ftd.
… of G4C2-toxicity. Loss of PAF1C reduced RNA and peptide expression from sense-G4C2 and antisense-G2C4 transgenes in Drosophila and in yeast. Importantly, components Paf1 and Leo1 were selective for expression from toxic (>30) G4C2-repeats versus inert (≤29) repeats, arguing selectivity to the …
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Endogenous glucagon-cells are necessary for the glucose-responsiveness of the HIT-T15 hamster β-cell line
… and glucose-dependent insulinotropic polypeptide (GIP) had no effect. When HIT-T15 cells were incubated in conditions of zero-glucose and glucose plus glucagon-Ab there was no significant difference in insulin release (p >0.05). Furthermore, glucagon-Ab inhibited glucose-stimulated insulin …