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Showing 1 to 12 of 12 for “"peptide processing"”.
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Measurement of neuropeptides: From presence to release
Characterization of neuropeptides is still actively underway. Various resources, both animal and instrument, were utilized to best answer the questions about the presence of peptides. Aplysia californica cerebral neurons were used to verify predicted peptide processing of the putative prohormone …
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An Apache Hadoop Framework for Large-Scale Peptide Identification
<p>Peptide identification is an essential step in protein identification, and Peptide Spectrum Match (PSM) data set is huge, which is a time consuming process to work on a single machine. In a typical run of the peptide identification method, PSMs are positioned by a cross correlation, a …
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Toward a Cell-Based Assay for Cubam-Mediated Intrinsic Factor-Vitamin B12 Binding and Uptake
… range. Possible explanations include signal peptide processing defects, limited secretory capacity, or degradation. The AMN plasmid was successfully constructed. The mini Cubilin-EGFP plasmid was successfully constructed using a two-step cloning strategy, and whole-plasmid sequencing …
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Contribution Of Non-Classical Antigen Presentation To Cd4+ T Cells During Orthopoxvirus Infection
… between the T cell receptor and an antigenic peptide in complex with an MHCII molecule on an antigen presenting cell. However, the primary means by which these peptides are generated and loaded onto MHCII molecules is debated. Historically antigen presenting cells have been thought to utilize …
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Circadian and Circatidal Rhythms of Protein Abundance in the Intertidal Mussel Mytilus californianus
… in cytoskeletal components, ER protein processing and vesicular trafficking, extracellular matrix and immune proteins, and oxidative stress and chaperoning proteins. We also found evidence that post-translational modifications may be important for driving these rhythms, as acetylation …
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Neuropeptidomics: MS-base peptide identification and quantitation study
… approach for the investigation of neuropeptides, often under specific physiological conditions. Neuropeptides comprise a complex set of cell-to-cell signaling molecules that are important in regulatory functions and behavior in the nervous system. Neuropeptide production typically …
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Studies on the Maturation of Secreted Quorum Sensing Peptides That Regulates S. Aureus Virulence
… the bacterium. Secretion of unique autoinducing peptides (AIPs) and detection of their concentration via AgrC, a transmembrane receptor histidine kinase, coordinates local bacterial population density with global changes in gene expression. In order for S. aureus to produce AIP, three proteolytic …
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Development of enabling technologies for single cell analysis with mass spectrometry
… islet cells were investigated and heterogeneous peptide processing was detected at the single cell level. With secondary ion mass spectrometry, disparate tissue from the mammalian nervous system was differentiated and further stratified into separate populations. A unique feature of such analyses …
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Single chain MHC trimer-based DNA vaccines for pathogen protection
… immunization approaches with class I binding peptides have failed to induce CD8+ T cell responses strong enough to prevent disease. This failure has been attributed to the lack of CD4+ T cell help and difficulty in maintaining a sufficient level of antigen presentation required for CD8+ T cell …
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Dynamic Responses at the Barrier Epithelium
… with the capacity to signal through various peptide hormones. These hormones regulate important aspects of local and organismal physiology. We discovered and characterized a prosecretory response of the mature enteroendocrine population to the pathogenic bacteria <italic>Pseudomonas …
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Cell Signaling Components of the Drosophila Circadian Pacemaker
… is mediated through the actions of the neuropeptide PDF: Pigment Dispersing Factor). Although increasing evidence suggests that downstream effectors differ between subgroups the molecular mechanisms of these differential responses remain unknown. Defining these mechanisms are of fundamental …
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Somatic regulation of germ cell development in the planarian Schmidtea mediterranea: the role of systemic and local factors
The student, Amir Saberi, accepted the attached license on 2016-07-12 at 15:54.