Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"peptide optimization"”.
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Discovery and Optimization of a Family of Naturally Encoded Antibiotic Compounds that Evade Antibiotic
… our lab previously discovered cilagicin, a lipopeptide natural product that shows robust Gram-positive antibiotic activity and evades antibiotic resistance even after prolonged pathogen exposure. This resistance evasion is attributed to a dual polyprenyl phosphate binding mechanism. In this …
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Exploring multivalency and chemical modifications in the development of anti-PD-L1 peptide inhibitors for cancer immunotherapy
… of target receptors. Over the past decade, peptides have garnered considerable interest as promising alternatives to address the limitations of existing anti-PD-L1 therapies and to overcome some of the drawbacks of mAb-based treatments. Compared to mAbs, peptides have better cell …