Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"peptide interactions"”.
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Experimental studies of zinc oxide and silica peptide interactions
… and properties of minerals. Understanding interactions during biomolecule-mediated synthesis is key to addressing the challenges that arise when designing new materials and synthesizing superior nanostructures, especially under aqueous conditions. The studies of peptide-mineral interactions …
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Computational modeling of protein-protein and protein-peptide interactions
Protein-protein and protein-peptide interactions play a central role in various aspects of the structural and functional organization of the cell. While the most complete structural characterization is provided by X-ray crystallography, many biological interactions occur in complexes that will not …
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Calmodulin and Calmodulin-Peptide Interactions: Structure, Energetics, and Dynamics
… in many eucaryotic cells. Understanding the interactions it makes with target proteins is central to understanding its role as a master regulator of cellular metabolism. Calmodulin is capable of binding dozens of target sequences, that share little sequence similarity, with high affinity and …
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Dynamic and kinetic investigations of SEM-5/SOS peptide interactions
The dynamics of SEM-5 SH3 domain protein can provide an important insight into how structural dynamics contribute to protein function. This is important because solving the structure of protein alone only provides the detail on the population weight average of native ensembles. NMR (Nuclear …
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Repetitions and Iterations: Novel Approaches to Characterize Protein-Peptide Interactions of Designed Armadillo Repeat Proteins by Solution NMR
About 15-40% of all interactions in the cell are estimated to be peptide-protein interactions and consequently designing a scaffold able to interact with a target peptide through a conserved binding mode has potentially many applications in the field of research, diagnostic and therapeutics. The …
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Determinants of protein-peptide interaction specificity in the Bcl-2 and TRAF families
Protein-peptide interactions have important roles in the majority of cellular processes. There are many families of peptide recognition domains in which homologous members display differential binding preferences for peptide sequence features. Peptide binding specificity is critical for the …
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Biophysical mechanisms of intrinsic protein disorder: lessons from a protein backbone model
… and aggregation of oligoglycine are due to intra-peptide interactions out-competing favorable peptide-solvent interactions, rather than an entropic or hydrophobic solvation penalty. We propose that the collapse and aggregation of IDRs devoid of hydrophobic residues are due to the same biophysical …
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SERS-active peptide nanoparticles for investigating protein allostery and bionanoassembly
… approach to investigate full-length MDM2 interactions with p53, thus providing an allosteric assay for identifying novel binding ligands. SERS (Surface enhanced Raman scattering) - active nanoparticles, functionalized with a p53 peptide mimic, peptide 12.1, display biologically specific …
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Solution Structure of the Apocalmodulin/neuro-P Complex
The interaction of apocalmodulin with a peptide (Neurop ) derived from the calmodulin-binding domain of the neural-specific protein neuromodulin has been studied by nuclear magnetic resonance (NMR). This complex is in fast exchange with its components on the NMR timescale, and the dissociation …
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Designing Peptide-Based Biosensors for the Diagnosis of Crystal Arthropathies
Peptides play a vital role in nature as they engage in many complex interactions which include forming proteins and binding with other biomolecules. The interactions between peptide and various biomolecules, such as proteins, carbohydrates, and enzymes, have been well-studied as they guide many …
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Simulating biochemical physics with computers
… in complex with CoREST and protein-substrate interactions of LSD1 with histone H3 tail. MD simulations of LSD1•CoREST complex bound to a 16 a.a. of the Nterminal H3-tail peptide (H3-p16) were carried out using NAMD to study the conformational flexibility of the protein complex, especially the …
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Structure and dynamics of membrane proteins from solid-state NMR
… intramolecular distances and probing the lipid-peptide and water-peptide interactions. Intermolecular 19F- 19F distances of the fluorinated peptides indicate that the MPER-TMD is a trimeric. In addition to membrane fusion proteins, we have studied the oligomeric structure and the zinc-bound …
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A Study of The Effect of Membrane Targeting Antimicrobial Compounds on Ionic Transport Across Lipid Bilayer Membranes
The novel synthetic cationic peptide melimine is a chimera of two natural peptides, melittin and protamine. This peptide has a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria while having no toxicity in mammalian cells. Melimine was initially …
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Beta-o-glicosilación de péptidos que incorporan aminoácidos no naturales
… acids and their corresponding model beta-O-glycopeptides, are reported. From this study, it can be concluded that the incorporation of non-natural amino acids allows us to modulate as desired the conformational space of the model glycopeptides. The different conformations exhibited by these …
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Protein/Peptide Recognition Modules in Cellular Signaling and HIV Pathogenesis
<p>The peptide-recognition domains play a key role in Eukaryotic signal transduction by mediating sequence-specific interactions with their protein/peptide ligands. In this thesis, I illustrate in molecular detail the recognition mechanisms utilized by three peptide-recognition domains: SH2 (Src …
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Investigations into the roles of bacterial TorD family chaperone proteins
… are targeted to the system by N-terminal signal peptides, which bear the consensus motif (S/T)RRxFLK. These proteins often require redox centres for function that must be incorporated prior to transport, with many utilising the molybdenum cofactor Mo-bis-MGD for enzymatic activity during …
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Effects of system complexity on protein aggregation in neurodegeneration
… studying the aggregation of recombinant Aβ (rAβ) peptide in vitro in presence of model lipid membranes. After describing the theoretical foundations of the study of protein aggregation via means of chemical kinetics, I will show how different lipid species affect the aggregation kinetics of rAβ42 …
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Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
Protein-protein interactions are essential for nearly every cellular process. Within signaling pathways, such interactions carry out numerous functions such as defining substrate specificity, inhibition of both other interactions and enzyme activity, localizing signaling partners, acting in a …
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Design of Collagen-Mimetic Peptides
… structures through self-assembly and/or through interactions with other biomolecules. One typical example of such supramolecular structure is the fibrils of collagen types I, II and III of the connective tissues. These fibrils have staggered arrangement of the laterally associated collagen triple …