Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"peptide inhibition"”.
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Investigation of Nonhydrolyzable ATP Analogues and Cofilin-Derived Peptides for Inhibition of Cofilin-Actin Rod Formation
… The goal of this research is to investigate peptide and small-molecules for their potential to inhibit actin-cofilin rod formation in cells. These inhibitors could form the basis for new Alzheimer's disease therapeutics. Using fluorescence microscopy and an optogenetic system known as …
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Peptide inhibitors of angiogenesis in endometriosis and the female reproductive system
… in endometriosis disease progression. The inhibition of blood vessel growth by anti-angiogenic agents is a potential strategy to manage endometriosis disease progression. This thesis investigated angiogenesis of endometriosis lesions, and evaluated a novel anti-angiogenic peptide as a …
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Rational Identification of Neuropilin-1 Inhibitors: From Deep-Learning to Drug Repurposing
… is addressed by the rational identification of peptide and small-molecule inhibitors that can disrupt engagement at the NRP1-b1 pocket, and by the establishment of methodological principles for their discovery and validation. A multimodal framework was assembled in which deep-learning–guided …
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Characterization and Inhibition of the Dimer Interface in Bacterial Small Multidrug Resistance Proteins
… TM4 dimer represents a potential target for SMR inhibition using a synthetic TM4 peptide mimetic. Using exponential decay measurements from a real-time cellular efflux assay, we observed the efflux decay constant was decreased by up to ~60% after treatment with the TM4 peptide inhibitor compared …
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Identification of A Conserved Cluster In The Rh Domain of Grk Critical For Activation By Gpcrs
… GRK5 or 6. Based on these results, we designed peptide mimetics of GRK5 helix 9 both computationally and through chemical modifications with the goal of both confirming the importance of helix 9 and developing a useful inhibitor to disrupt the GPCR-GRK interaction. Several peptides were found to …