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Showing 1 to 3 of 3 for “"peptide hydrolysis"”.
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Nucleobase-modified deoxyribozymes for amide and peptide hydrolysis
… from pools of random DNA sequences, no inherent peptide sequence biases must be overcome during the selection process, and thus the prospect of truly selective artificial proteases is reasonable. Previous efforts seeking DNA-catalyzed peptide cleavage resulted in the identification of …
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Regulation of ClpP : role of substrate gating and activation by ClpX
… of ClpP, where rapid and relatively non-specific peptide hydrolysis generates small peptide products. Prior work had shown that ClpP is unable to degrade polypeptides in the absence of ClpX, suggesting the existence of a mechanism that inhibits the activity of free ClpP. Structures of free ClpP …
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Leveraging Bio-Inspired Molecules for Cancer Theranostics
… most promising of tumor targeting molecules are peptides and antibodies. These bio-inspired molecules can be designed and synthesized to target and respond to cancer cells based on the properties of those cells. Matrix metalloproteinase (MMP) enzymes are over-expressed by some metastatic cancers, …