Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"peptide hydrogels"”.
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Self-assembled Peptide Hydrogels for Therapeutic H2S Delivery
… compound, were synthesized and conjugated to peptide sequences to form H2S-releasing aromatic peptide amphiphile (APA) hydrogels. APAs formed nanofibers, which were stabilized by beta-sheets and aromatic stacking. The self-assembled structures were affected by the substituents on the aromatic …
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Peptide hydrogels as novel scaffolds for dental pulp cell culture
… in vitro with inhouse synthesised ultrashort peptide hydrogels (NapFFKK-OH and NapFFK’K’-OH) as well as commercially available Biogelx hydrogels containing different percentages of RGD. Results showed that 0.5% w/v NapFFK’K’-OH hydrogel and 10% RGD Bioglex hydrogel were most promising for 3D …
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Functionalising peptide hydrogels to improve drug delivery for the treatment of glioblastoma
… tumours. Using a tissue-specific self-assembling peptide (SAP) hydrogel as the delivery vehicle, here we developed an injectable and biocompatible drug delivery system that can be implanted post-operatively to release anticancer drugs directly at the site of resection. We demonstrate that the …
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Functionalising peptide hydrogels to improve drug delivery for the treatment of glioblastoma
… tumours. Using a tissue-specific self-assembling peptide (SAP) hydrogel as the delivery vehicle, here we developed an injectable and biocompatible drug delivery system that can be implanted post-operatively to release anticancer drugs directly at the site of resection. We demonstrate that the …
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Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery
… thesis was to advance the use of self-assembling peptide hydrogel scaffolds for cartilage repair by encapsulating bone-marrow-stromal cells (BMSCs) and incorporating chondrogenic cues to stimulate differentiation and neotissue production. To test the hypothesis that self-assembling peptide …
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Targeted Gene Therapy Approaches for Huntington's Disease: Advancing Treatment through Bioengineered Self-Assembling Peptide Hydrogels and BDNF-Encoded Adeno-Associated Viruses, Applied In Vitro and In Vivo
… viral-based gene delivery. Self-assembling peptide (SAP) hydrogels are fabricated from detectable peptide sequences of tissue-specific ECM proteins to not only mimic native ECM biochemically but also provide nanofibrous structural support to enhance and control tissue renovation. These SAP …
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Targeted Gene Therapy Approaches for Huntington's Disease: Advancing Treatment through Bioengineered Self-Assembling Peptide Hydrogels and BDNF-Encoded Adeno-Associated Viruses, Applied In Vitro and In Vivo
… viral-based gene delivery. Self-assembling peptide (SAP) hydrogels are fabricated from detectable peptide sequences of tissue-specific ECM proteins to not only mimic native ECM biochemically but also provide nanofibrous structural support to enhance and control tissue renovation. These SAP …
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Enzymatic crosslinking of dynamic hydrogels for in vitro cell culture
… To address this issue, four-dimensional (4D) hydrogels (i.e., 3D materials permitting time-dependent control of matrix properties) are proposed to recapitulate dynamic changes of ECM properties. The goal of this thesis was to exploit orthogonal enzymatic reactions for on-demand stiffening …
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Synthesis, evaluation, and applications of hydrogen sulfide-releasing supramolecular materials
… over a range of pH conditions of a series of peptides containing H2S-releasing S-aroylthiooximes (SATOs). The SATO-peptides showed structure–reactivity relationships with SATO ring substituents playing a crucial role in hydrolysis rates. Electron-donating substituents accelerate the rate of …
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Nanofiber characterization of self-assembling peptides RAD16 and RID 12
Self-assembling peptides are quickly proving themselves useful in tissue engineering and most recently, electronics. Self-assembling peptides have been shown to form a network of nanofibers that can be used in scaffold research or as templates for nanowires. However, self-assembling peptides have …
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Mechanical behavior and microstructure of self-assembling oligopeptide gels
Hydrogels have become widely used in the fields of tissue engineering and drug delivery. One class of hydrogel is formed from synthetic oligopeptides that self-assemble into a solution of beta-sheet filaments. These filaments can aggregate to form a gel suitable for culture of various cell types. …
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In vitro culture of a chondrocyte-seeded peptide hydrogel and the effects of dynamic compression
… geometry. In these studies, a self-assembling peptide hydrogel is evaluated as a potential scaffold for cartilage repair using a model bovine cell source. A seeding technique is developed for 3-D encapsulation of chondrocytes in a peptide hydrogel. The chondrocyte-seeded peptide hydrogel was …
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The Neurogenic Capacity of Müller Glia and Synaptic Remodeling in the Mammalian Retina: Implications for Regenerative Therapies
… glia were cultured in three dimensional (3D) peptide hydrogels. Cells encapsulated within 3D hydrogels expressed different neuronal genes, compared to cells cultured on 2D flat plastic substrates. The roles of RE-1 silencing transcription factor (REST) and Notch signaling in Müller glia …
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Supporting bone regeneration: Evaluation of endocrine peptides and delivery systems for local application of lactoferrin
… to evaluate the myokine irisin and the neuropeptide orexin as potential bone anabolic factors and to develop a clinically suitable drug delivery system for the optimal delivery of the bone anabolic factor lactoferrin (LF). Methods We developed an ex vivo osteocyte culture system, and …
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Developing osteoarthritis treatments through cartilage tissue engineering and molecular imaging
… potential therapies. Agarose and self-assembling peptides have been used to make hydrogels for in vitro culture of bovine bone marrow stromal cells (BMSCs) which can differentiate into chondrocytes, undergo chondrogenesis, and produce cartilage tissue. So far, differences in cell morphology that …
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In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds
… and to test the ability of a self-assembling peptide scaffold, (KLDL)3, with or without growth factors to augment repair. Delivery methods included growth factor adsorption, scaffold-tethering, and modification of growth factor structure. (KLDL)3 was modified to deliver IGF-1 and TGF-[beta]1 …
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Stimuli-Responsive Peptide-Based Biomaterials: Design, Synthesis, and Applications
Peptide-based biomaterials have gained much interest in various applications in drug delivery and tissue engineering in recent years, in large part due to their typically excellent biocompatibility and biodegradability. Composed of different amino acids, peptides can be designed with numerous …