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Showing 1 to 20 of 41 for “"peptide hormone"”.
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The secretory pathway in peptide hormone-producing cells
Contains fulltext : mmubn000001_234153458.pdf (Publisher’s version ) (Open Access)
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Pancreatic peptide hormone expression in the RINm5F cell line
… the results from work aimed at determining which hormone-producing phenotypes were expressed under routine and modified culture conditions. Insulin, detected by immunoperoxidase labelling at earlier passages, was not detectable in later passages of RINm5P:-MRC cultures. Immunoblots and …
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Angiotensin-(1-7): A Peptide Hormone Inhibitor for the Treatment of Breast Cancer Targeting the Tumor Microenvironment
… [Ang-(1-7)], an endogenous seven amino-acid peptide hormone of the renin-angiotensin system, inhibits the growth of HER2-amplified and ER-positive orthotopic breast tumors and to identify the molecular mechanisms for the Ang-(1-7)-mediated reduction in tumor growth. BT-474, which express the …
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Aspects of structure-activity relationships and physiology of gastrin and related peptides
When, in 1973, I embarked upon this study, the hormone gastrin seemed a suitable hormone to study with regard to investigation of structure-activity relationships and physiology of a peptide hormone. Gastrin was best known at that stage as a linear peptide comprising 17 amino acids, which was …
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The Effect of Steroid Hormones on Expression of the Leptin Receptors
Leptin, a peptide hormone secreted by adipocytes, has been widely studied in the attempt to understand its contributions and relation to obesity. There is a sexual dimorphism in leptin levels between men and women, suggesting a possible influence of steroid hormones on leptin expression and …
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HORMONE AND FLAVONOL REGULATION OF MAMMALIAN METABOLIC SIGNALING PATHWAYS
… Both obesity and T2DM are linked to altered peptide hormone signaling, including insensitivity to insulin and leptin. Research in this dissertation investigated how gender, weight loss, and diet components affected signaling pathways that are dysregulated in obesity and T2DM. Chapter II …
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Angiotensin-(1-7) Reduces Prostate Cancer Growth and Metastasis by Altering the Tumor Microenvironment
Ang-(1-7) is an endogenous peptide hormone that is produced in the circulation and in tissues by proteolytic cleavage of angiotensin I or II. The heptapeptide mediates biological responses by activating a unique G-protein-coupled angiotensin-(1-7) [AT(1-7)] receptor mas, thereby providing specific …
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Studien zur kontrollierten Freisetzung biologisch aktiver Substanzen aus resorbierbaren Nano- und Mikrosphären
… and for drug targeting. Using acetylic acid, the peptide hormone insulin and the serin protease thrombin studies were carried out to evaluate the impact of several process parameters of the emulsion-evaporation-method on the sphere morphology and their drug release behaviour. By immobilizing of …
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Expression of recombinant porcine preprorelaxin in Nicotiana tabacum
Relaxin is a small peptide hormone that has demonstrated potential therapeutic actions for cardiovascular disease and fibrosis. Additionally, relaxin has demonstrated the ability to protect the heart from injuries caused by ischemia and reperfusion, promote the healing of ischemic ulcers, and …
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Defining a Neuroprotective Pathway for the Treatment of Ataxias
… the up-regulation in the cerebellum of the peptide hormone Cholecystokinin (Cck) in these mice. Knocking out Cck or the Cck1 receptor (Cck1R) in ATXN1[30Q]D776 mice confers a progressive disease where PC death occurs by thirty-six weeks of age. Weighted Gene Co-expression Network Analysis …
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Thioamides And Proteolysis: Examining The Effects And Applications Of A Single-Atom Substitution
Thioamide substitution in the peptide backbone enables several applications in studying proteolysis, monitoring protease activity and in selective protease inhibition. To date, we have used model substrates to investigate the positional effects that these thioamide substitutions have on proteolysis …
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The synthesis and evaluation of small organic molecules as cholecystokinin antagonists
Cholecystokinin (CCK) is a peptide hormone, present in the alimentary and the CNS. It is the most abundant peptide in the brain. CCK has been implicated in a number of disorders. The link between CCK and anxiety was the basis for this research. A comprehensive discussion on the many types of CCK …
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Structural and Functional Insights into Ghrelin Acylation by Ghrelin O-Acyltransferase
<p>Ghrelin is a peptide hormone primarily secreted by the stomach that acts as the endogenous ligand for the GHSR1a G-protein-coupled receptor. This 28 amino acid peptide stimulates appetite and has been associated with the cardiovascular, gastrointestinal, neuroendocrine, and immune systems. …
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Enzymology and inhibition of ghrelin acylation by ghrelin O-acyltransferase
<p>Ghrelin is a circulating peptide hormone that plays a regulatory role in many physiological processes related to energy balance and metabolism. To be recognized by its receptor, growth hormone secretagogue receptor 1a (GHSR1a), the serine 3 residue of ghrelin must be octanoylated. This unique …
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The structure and function of the human ghrelin receptor
The peptide hormone, ghrelin, exerts its physiological effects through a G-protein-coupled receptor called the ghrelin-R. The ghrelin-R displays a high degree of constitutive activity, signalling through the inositol phosphate pathway in the absence of bound agonist. TMs III and VI have been …
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Studies on Solid-Phase Peptide Synthesis: The Synthesis of Glucagon
… approach was studied in the synthesis of the peptide hormone glucagon. The choice of this molecule was based upon: (1) the unusual chemical structure; (2) biological significance. The main features of the strategy employed are: (1) the use of Biphenylisopropyloxycarbonyl group (Bpoc) for …
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Evaluation of radiolabelled hynic-salmon calcitonin analogues as imaging agents for multiple myeloma and characterisation of novel hynic derivatives as chelators for technetium
Calcitonin is a peptide hormone produced by the C-cells of the thyroids. Calcitonin receptors (CTR) are expressed by osteoclasts in the normal bone and in many cancers such as multiple myeloma (MM), breast and prostate cancer. In this thesis we report on the synthesis and evaluation of Tc-99m …
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Ryanodine receptor expression in trophoblasts
… Furthermore, endogenous placental peptide hormones, namely angiotensin II, arginine vasopressin and endothelin 1, were demonstrated to increase [Ca2+]i in BeWo cells, and such increases were suppressed by RyR antagonists and by blockers of the corresponding peptide hormone …
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The MA-10 Cell Line as a Model of insl3 Regulation and Leydig Cell Function
… produce testosterone in response to luteinizing hormone (LH) via the cyclic adenosine monophosphate (cAMP)/protein kinase A pathway. Additionally, these cells are responsible for producing insulin-like peptide 3 (INSL3), a peptide hormone that is essential for testicular descent. The …
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
High serum levels of the peptide hormone prolactin are associated with increased breast cancer risk and poor prognosis. Prolactin is also involved in breast cancer resistance to different chemotherapeutics. The overall goal of this project is to investigate potential pathways involved in prolactin …
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