Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"peptide engineering"”.
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PEPTIDE ENGINEERING FOR DEVELOPMENT OF ANTIMICROBIALS AGAINST Mannheimia haemolytica
… have shown poor vaccine efficacy. Antimicrobial peptides (AMPs) may help in the management of respiratory disease caused by M. haemolytica while minimizing the risk of drug residues in animal-derived food products. AMPs are positively charged molecules that can kill bacteria primarily through the …
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Investigations of the Substrate Specificity of Lacticin 481 Synthetase and Utilization in Peptide Engineering Applications
The promiscuous activity of LctM toward LctA prepeptides containing nonproteinogenic amino acids prompted the evaluation of LctM as a general catalyst for the introduction of post-translational modifications in non-lantibiotic peptides fused to the LctA leader peptide. LctM was utilized to …
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From Peptide Precursors to Lanthionine -Containing Peptide Antibiotics Using the First Isolated and Active Lacticin 481 Synthetase: Mechanistic Studies and Peptide Engineering
… treatment with the protease Lys-C, the modified peptide in the absence of the leader sequence and the first Lys residue showed biological activity. Mechanistic studies with the active LctM disclosed that the activity of LctM absolutely requires both Mg2+ and ATP. The products of ATP were …
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Towards Inhibition of Oncogenic RhoA Signaling using Stapled Peptides
… including the Ras superfamily of small GTPases. Peptide therapeutics are emerging as promising new modalities to more efficiently inhibit these "undruggable" targets. RhoA is a member of the Rho family within the Ras superfamily of small GTPases and is a major regulator of cytoskeletal …