Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"peptide editing"”.
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Molecular basis of TAPBPR-mediated peptide editing on MHC class I molecules
… of the cellular proteome, in the form of short peptides, to the cell surface for the inspection by cytotoxic T cells. This process is a crucial immunosurveillance mechanism used to induce appropriate immune responses against intracellular pathogens and cancer. In order to generate optimal T …
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Utilising recombinant TAPBPR technology to investigate MHC class I peptide editing and therapeutic applications
… to infection and malignancy by presenting peptides to CD8+ T cells. Optimal peptide:MHC-I complexes are generated in the MHC-I antigen processing and presentation pathway. In this pathway, TAPBPR shapes the presented peptidome by catalysing peptide exchange on MHC-I molecules and promoting …
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Diversity and Evolution in the Avian Major Histocompatibility Complex
… flexibility in the system. Finally, a family of peptide editing genes, of which one, TAPBPL, is notably absent in placental mammals, was investigated using genomic databases to assess phylogenetic distribution and biochemical methods to investigate function and regulation. At all scales, …
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Exploiting the Molecular Mechanisms of TAPBPR for use in Cancer Immunotherapy
… for shaping the immunopeptidome via MHC-I peptide editing and the recycling of sub-optimally loaded MHC-I to the peptide loading complex. As such, TAPBPR plays an essential role in the activation of the immune system against infection and cancer, ensuring that only high affinity peptides …