Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"peptide drugs"”.
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Identification, Molecular Cloning and Functional Characterisation of Novel Bioactive Peptide Drugs from Amphibian Skin Secretions
… and DNA sequencing were applied. The novel peptide sequences were deduced from cloned cDNAs and then confirmed by using MALDI-TOF mass spectrometry and MS/MS fragmentation sequencing. Finally, three novel peptides were chemically-synthesised. <br/><br/>The determination of the therapeutic …
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Pre-clinical development of cyclodextrin-based nanoparticles for oral delivery of protein/peptide drugs-in vitro and in vivo evaluation
Over the past decades, oral protein delivery has become a major research area for pharmaceutical companies. Ideally, once the protein is orally administered, it should remain stable until it reaches the targeted site of absorption in spite of the myriad of factors that could hinder its stability, …
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Computational design of functional cyclic peptides using deep learning
Cyclic peptides have gained significant traction as a therapeutic modality. Given their ease of synthesis, expansive chemical space, and the promising pharmacokinetic properties of existing cyclic peptide drugs, cyclic peptides have been proposed as a mid-point between biologics and small …
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Syntax of Phase Transition Peptide Polymers with LCST and UCST Behavior
… and medicine. Currently, however, only few peptide polymers are known to display this behavior. Here, we uncover the syntax -- defined as the arrangement of amino acids (letters) into repeat units (words) that have a functional behavior of interest -- of a novel and extensive family of …
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QUB-1073: a bioactive peptide from the skin secretion of Phyllomedusa rohdei
… to examine the characteristics of a bioactive peptide (QUB-1073) from the skin secretion of Phllomedusa rohdei and to determine the pharmacological activity on rat uterus and urinary bladder smooth muscle. <br/>A variety of biologically active peptides, including some new antimicrobial peptides …
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Identification and rational design of Bowman-Birk type protease inhibitory peptides derived from Ranidae frogs
… natural active compounds has provided more new drugs that are independent of natural resources. The catalogues of peptides in skin secretions of different species show incredible structural and functional diversity which have irreplaceable value in biomedical research and natural drug …
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The Development of Methods for Generating Fc-Conjugates and Antibody-Drug Conjugates
Biotherapeutics, such as peptides and proteins, constitute a valuable class of drugs due to their high target specificity and their ability to modulate protein interactions (PPIs), which are often considered ‘undruggable’ by traditional small molecule drugs. Additionally, antibodies possess many …
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A novel polyelectrolyte complex between amphiphilic poly (allyl amine) and sodium alginate.
… interesting results in the field of protein and peptide delivery. Peptides and proteins are natural polyelectrolytes, and have been used in combination with other charged polymers in the delivery of peptide drugs. The oral route of delivery for peptides and proteins has many barriers, but is of …
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Controlled release of GLP-1 from affinity-based protein microspheres and quantitative analysis of the role of fiber length on phagocytosis and inflammatory response by macrophages
Peptide drugs are highly specific and efficacious; interest in them remains high despite the challenges of rapid clearance and degradation. To overcome these limitations peptide delivery systems must prolong release while protecting biological activity. Glucagon-like peptide 1 (GLP-1) stimulates …
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Protein and peptide-based biomaterials for treatment of COVID-19, crossing the blood-brain barrier and local delivery of antibiotics
… objectives. The first one is to discover novel peptide shuttles that can effectively transport different molecules across the Blood-Brain Barrier (BBB) and into the brain. Despite all the advancements in science and technology, discovering new shuttles that can effectively deliver drugs to the …
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Evaluation of the oral delivery of goserelin with Pheroid® technology
The therapeutic amphiphilic peptide, goserelin, being investigated in these studies, is a type of hormone therapy generally used in addition to standard adjuvant therapy. Goserelin serves as treatment for numerous hormone-dependent disorders, for instance benign conditions (e.g. uterine fibroids, …