Global ETD Search
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Showing 1 to 3 of 3 for “"peptide conjugation"”.
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Peptide conjugation to enhance oligonucleotide delivery
… the molecule of interest to a cell-penetrating peptide (CPP). CPPs are widely employed to enhance macromolecule delivery, with hundreds of different peptides and modifications reported to improve cellular uptake. In this thesis, CPPs were systematically investigated and chemically altered to …
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Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting
<p>Peptide-drug conjugates (PDCs) have emerging applications in the safer delivery of chemotherapeutics to the site of diseases to avoid the side effects associated with the drug. PDCs also improve the physicochemical property of the anticancer drug. Therefore, we have designed and synthesized …
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Novel functionalised biodegradable polymeric micro- and nano-structures for tissue engineering and drug delivery applications
… into the polymer chain for subsequent covalent conjugation of biologically important molecules. <br/><br/>Chapter One provides a detailed look at ‘living’ polymerisation techniques, RAFT polymerisation and ROP and their use in the preparation of polymers for biomedical applications. <br/><br/>In …