Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"peptide analogs"”.
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Structure studies of the human class II major histocompatibility complex protein HLA-DR1
… that bind antigens in the form of short peptides within the cell and present them to the T cell receptors on the surface T cells. In this thesis work, the structural aspects of the human class II MHC protein HLA-DR1 in complex with different peptides and also in the peptide-free form were …
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Conformational and docking studies of Gonadotropin releasing hormone and its analogsby NMR spectroscopy and molecular modelling
Gonadotropin releasing hormone (GnRH) is a decapeptide with blocked amino and carboxy termini and plays a central role in reproduction. Mammalian GnRH has a positively charged Arg8 residue and binds to the mammalian receptor with high affinity. However, the neutral analog Cln8GnRH has very low …
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Crystallographic, Molecular Dynamics, And Enzymatic Studies Of Multi-Drug Resistant Hiv-1 Protease And Implications For Structure Based Drug Design (project 1); Crystallographic Studies Of Human Myelin Protein Zero (project 2)
… reveals the realignment of the substrate peptide in the MDR769 HIV-1 protease, making it less accessible to the Asp25 and Asp 125 amino acid residues in the active site. This finding indirectly indicates the reduced catalytic activity of MDR769 HIV-1 protease in substrate cleavage compared …
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Development of Non-Atp Competitive, Plk1-Selective Inhibitors
… REPLACE uses structure activity relationships of peptide inhibitors to generate a pharmaceutically acceptable lead molecule by replacing individual amino acid residues with non-peptide fragments. REPLACE was used to identify fragment mimetics for determinants from the endogenous phosphopeptide …
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NTS2-selective analogs as an alternative treatment to chronic pain
… focused on the development of neurotensin (NT) analogs selective for the NTS2 receptor, which is not associated with NTS1-mediated secondary effects. First, a series of peptide analogs was synthesized with different modifications to NT(8-13) peptide to improve its pharmacological properties as …
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Part I: Disruption of PTEN-5-HT2CR Coupling: A Potential Treatment for Restoration of 5-HT2CR Function / Part II: Rapid Total Synthesis of Cyclodepsipeptide MA026
… to be preserved in the future design. Cyclic peptide 1, 2, peptidomimetic 31, and 56 with relatively good inhibitory effect of interfering with PTEN-5-HT2CR coupling were obtained. More peptide analogs, turn peptidomimetics, and looped conformation peptide mimetics were also provided for …
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Design of Non-ATP Competitive and Cell Cycle Specific CDK Inhibitors Targeting Cyclin Binding Groove
… C-terminal phenylalanine in p21 and p107 derived peptides were used to probe their binding to the specific primary hydrophobic pockets of CDK2/A2 and CDK4/D1 due to a Leu/Val exchange in CBGs. A 3-thienylalanine replacement in SAKRRLFG (p107) context was found to be more potent than the parent …
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Design of Peptide Ligands for 14-3-3ε, and Exploring the Role of Residue Types in Ligand Recognition by 14-3-3 Proteins
… group developed two novel, 14 amino acid residue peptides; Ac-CDC25A(173-186)-NH2 (pS), and Ac-CDC25A(502-515)-NH2 (pT), corresponding to two binding regions of CDC25A to 14-3-3 proteins. Both pS and pT bind 14-3-3ε, and induce cell death of cSCC cells, albeit at a high IC50. In the work presented …
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Importance of the Gastrin N-Terminal Region in Binding and Activation of the Putative G17-Gly Receptor on Human Colonic Carcinoma Cells
… has indicated that the N-terminal portion of the peptide likely plays a role in the promotion of proliferation of cancer cells in vitro, binding to low and high affinity sites which may jointly regulate cell proliferation. Consequently, C-terminally truncated G17 analogs were synthesized and their …
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Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
Radiolabeled receptor-binding peptides have emerged as an important class of radiopharmaceuticals for diagnostic imaging and cancer therapy. Following radionuclide labeling, the specific receptor-binding properties of the ligand can be exploited to guide the radioactivity to tissues expressing a …
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Structural and Biological Characterization of Antimicrobial Peptides from Rana Sylvatica and Kassina Senegalensis
Gene-encoded antimicrobial peptides are an important component of host defense in both invertebrates and vertebrates, ranging from insects to mammals. Although these peptides are usually isolated in high concentrations, they possess varying potencies against microorganisms. In this study, three …
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Modulation of the T cell response with MHC class I peptides and their analogues
… T cells specifically recognize donor MHC-derived peptides. This implies that it may be possible to develop antigen-specific strategies in order to modulate the alloimmune response by peptide analogues and specifically altered peptide ligands. The purpose of this study was to explore the potential …