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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"peptide aggregation"”.
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Kinetics of Peptide Aggregation
… it can be formed from a host of proteins or peptides simply by denaturing them enough to form a cross-beta secondary structure and has a modulus of >10 GPa. As a general reference, "protein" is usually a very high molecular weight, naturally occurring molecule and "peptide" is a much smaller …
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EXPLORING THE EFFECTS OF PHYSIOLOGICAL ENVIRONMENT ON AMYLOID AGGREGATION
Molecular level self-assembly/aggregation processes are common in biomolecular systems. Specifically, aggregation of protein molecules results in formation of amyloid deposits, that has been associated with neuronal dysfunction leading up to neurodegeneration. The protein aggregation is often …
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Amyloid β Aggregation is Coupled to Cellular Metabolism and Intramitochondrial Proteostasis
… age-associated disorders characterised by peptide aggregation, such as Alzheimer's disease (AD), become more prevalent. Research efforts have aimed to unveil the underlying mechanism of disease pathogenesis in order to develop potential therapies. In particular, reports have focused on …
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Membrane fragmentation by a 20-29 fragment of human islet amyloid polypeptide and rat amyloid polypeptide
… cells. The amyloidogenic human Islet Amyloid Polypeptide (hIAPP, also known as human amylin) is believed to play a crucial role in this biological process. Previous studies have shown that hIAPP forms small aggregates that kill β-cells by disrupting the cellular membrane. In this study we report …
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Composition, thermodynamics, and morphology: A multi-scale computational approach for the design of self-assembling peptides
Peptide self-assembly has generated significant interest as a means for the bottom-up fabrication of highly tunable biocompatible nanoaggregates. Individual peptides can be synthesized to include non-natural π-conjugated subunits, endowing assembled aggregates with a range of optical and electronic …
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Model membrane interactions with ions and peptides at the air/water interface
The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated biochemical processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. …
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Electrocatalytic Oxygen and Nitrate Reduction Reactions Using Cu-Based Electrodes
… and develop new ORR electrocatalysts using Cu tripeptide complexes. Laccase is a well-known Cu-containing ORR enzyme with a low overpotential, but it is only stable in a narrow pH range. Here, we synthesized Cu-tripeptide complexes and investigated their ORR activities in a wide pH range from 2.5 …
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Microfluidic device and interfacial transport: application to biomolecules and nanostructures
… process. The oligomerization of A40 peptide in microconfined environment represents a new investigation of the extensively studied peptide aggregation. The added value of the approach I devised is the precise control on the local concentration of peptides together with the possibility …
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Studies of the Physical Stability of GLP-1 & Chemically Modified Forms of GLP-1
Biopharmaceuticals, including proteins and peptides, are becoming increasingly important as therapeutic agents. However, the clinical use of protein and peptide therapeutics is still restricted due to undesirable properties such as their ability to self-assemble and aggregate. These properties not …
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Polysaccharides in Amyloid Aggregation and Hydrogel Mechanics: Insights from Molecular Modeling
… applications and disease-related amyloid aggregation. A common theme among them is the inherent dynamics and polymorphism of self-assembled structures, which pose challenges to complete characterizations with experimental techniques. We addressed the knowledge gaps in the experimental …
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The impact of moisture-induced aggregation of soy protein isolate and hydrolysate during storage on product and nutritional quality
… during processing and distribution proteins/peptides tend to aggregate when introduced to increased temperatures and relative humidity. When aggregation occurs in a dry protein powder, there is a decrease in processability, product quality, and consumer acceptability. It is therefore …
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Structural Analysis of Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channel Protein and Proline Mimics using Computational Techniques
… derived in order to address the solubility and aggregation difficulties that can arise when performing FMOC solid phase synthesis of peptides.<sup>60</sup> The presence of pseudoproline in a peptide overcomes aggregation by disrupting helices and β-sheets; leading causes in peptide …
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Studies on the physical stability of a C-terminally amidated variant of GLP-1
The phenomenon of peptide and protein aggregation is of great biochemical importance. Not only is it a key feature of numerous neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease, but it also plays a significant role in the manufacturing and processing of therapeutic …
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Microfluidic-based continuous self-assembly, alignment, and printing of oligopeptides with π-conjugated cores accompanied by advanced single molecule characterization
… techniques to a new class of functionalized peptides. Soon after its inception, I took over that work and have continued efforts to optimize devices and hone the techniques of their use in order to create a platform for high-throughput production of exceptionally aligned oligomer fibers. …