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Showing 1 to 20 of 3443 for “"peptide"”.
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Atrial natriuretic peptide
Contains fulltext : mmubn000001_08730127x.pdf (Publisher’s version ) (Open Access)
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Plant production of Gonococcal peptide vaccine, candidate peptide display with HPVs
… design involves the incorporation of a gonorrhea peptide, mimicking the 2C7 epitope of the surface molecule LOS on gonorrhea, into the surface DE loop of HPV16 virus-like particles (VLPs). These chimeric VLPs as well as HPV16 VLPs were expressed and successfully purified from plants and …
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Regulation of natriuretic peptide system activation:effects of spontaneous natriuretic peptide mutations and identification of novel natriuretic peptide receptor phosphorylation sites.
… mediate the physiologic effects of natriuretic peptides, including reduction of blood pressure and blood volume, stimulation of long bone growth, and regulation of cardiac size. Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) signal through GC-A while C-type natriuretic …
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Heterocycles in peptide chemistry
… to restrict the conformational freedom of the peptide.<br></br><br></br> Cycloaddition of a nitrile oxide, derived from a Boc-protected naturally-occurring a-amino acid, with a pyrrolidine en amine led to a Boc-protected 3-aminoalkylisoxazole amino acid ester. The nitrogen and carbon termini of …
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Automated flow peptide synthesis
… nearly sixty years ago, batch solid phase peptide synthesis remains slow at minutes to hours per residue. Here we report a fully automated, flow based approach to solid phase polypeptide synthesis with amide bond formation in seven seconds and total synthesis times of forty seconds per …
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Kinetics of Peptide Aggregation
… it can be formed from a host of proteins or peptides simply by denaturing them enough to form a cross-beta secondary structure and has a modulus of >10 GPa. As a general reference, "protein" is usually a very high molecular weight, naturally occurring molecule and "peptide" is a much smaller …
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From Peptide Precursors to Lanthionine -Containing Peptide Antibiotics Using the First Isolated and Active Lacticin 481 Synthetase: Mechanistic Studies and Peptide Engineering
… treatment with the protease Lys-C, the modified peptide in the absence of the leader sequence and the first Lys residue showed biological activity. Mechanistic studies with the active LctM disclosed that the activity of LctM absolutely requires both Mg2+ and ATP. The products of ATP were …
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Design and synthesis of handles for solid-phase peptide synthesis and convergent peptide synthesis
The recent popularity of methods for solid-phase peptide synthesis that use the 9-fluorenylmethyloxycarbonyl (Fmoc) group for N<sup>α</sup>-amino protection has created a need for compatible anchoring linkages and handles. In an effort to develop mild new methods for use in solid-phase peptide …
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Study of peptide-mineral interactions
The studies of peptide-mineral interactions presented within this thesis aimed to identify and understand the effect(s) induced by peptides/selected motifs on amorphous silica and crystalline zinc oxide (ZnO) formation. The effect of imidazole functionality on silica formation was studied using …
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Distributed Approach for Peptide Identification
<p>A crucial step in protein identification is peptide identification. The Peptide Spectrum Match (PSM) information set is enormous. Hence, it is a time-consuming procedure to work on a single machine. PSMs are situated by a cross connection, a factual score, or a probability that the match between …
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Mechanisms of dendritic peptide release
… neuronal dendrites, especially the mechanism for peptide release. One theory is that vesicles stored in dendrites are non-released vesicles ready for recycling or degradation. Immunofluorescent labelling was performed on hypothalamic slices of the transgenic rat where enhanced green fluorescent …
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Defining peptide structure with metathesis.
… Herein describes studies on the control of peptide structure and function through synthetic modifications, for the synthesis of novel enzyme inhibitors and biomaterials, primarily using olefin metathesis chemistry. Metathesis is chosen for the manipulation of peptide structure in order to …
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Newer methods in peptide chemistry.
Massachusetts Institute of Technology. Dept. of Chemistry. Thesis. 1970. Ph.D.
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Lariat peptide inhibitors of Abl kinase
… adjacent to the adenine-binding pocket. Small peptides that can function as adenosine triphosphate (ATP) competitive inhibitors would prove useful in identifying and validating new druggable surfaces in the kinase catalytic cleft. These peptides, being larger than small molecules, have the …
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Entwicklung influenzabindender Peptide für die Biosensorik
… Antikörpers wurden drei lineare Peptide abgeleitet. Die Bindungseigenschaften der drei Peptide wurden experimentell mittels Oberflächenplasmonenresonanzspektroskopie untersucht. Es zeigte sich, dass in Übereinstimmung mit begleitenden Molekulardynamik-Simulationen zwei der drei …
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Synthesis of aromatic peptide nucleic acids
The synthesis of two analogues of Aromatic Peptide Nucleic Acids (APNAs) monomers was successfully achieved. These Peptide Nucleic Acid analogues could be used as building blocks for the synthesis of oligomers with the DNA and RNA recognition properties of PNAs in addition to a more hydrophobic …
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Chlorinated amino acids in peptide production
A new method for the production of peptides through biological expression was developed, utilising lactonisation-prone chlorinated amino acids for latent peptide bond digestion. Incorporation of halogenated amino acids into proteins is possible due to the inherent inability of the biological …
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GDGT liposomes for oral peptide delivery
Τα αρχαία αποτελούν διακριτή επικράτεια της ζωής και χαρακτηρίζονται από τη μοναδική δομή των μεμβρανικών τους λιπιδίων, τα οποία φέρουν ισοπρενοειδείς αλυσίδες συνδεδεμένες με αιθερικούς δεσμούς. Χάρη στα ιδιαίτερα αυτά χαρακτηριστικά, τα λιπίδιά τους μπορούν να σχηματίζουν εξαιρετικά σταθερά …
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Chlorinated amino acids in peptide production
A new method for the production of peptides through biological expression was developed, utilising lactonisation-prone chlorinated amino acids for latent peptide bond digestion. Incorporation of halogenated amino acids into proteins is possible due to the inherent inability of the biological …
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Myoglobin Microsperes and Metalloporphyrin -Peptide Complexes
… and characterized a new class of heme-peptide complexes using disulfide-linked tweezers and cyclic peptides. The binding affinities, helicities, and mechanism of binding of linear, tweezers, and cyclic peptides to [Fe III(coproporphyrin-I)]+ have been determined. We have incorporated …
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