Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 124 for “"peptidase"”.
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Characterization of the transcriptome and the peptidase and the non-peptidase homologs of callosobruchus maculatus
… parts of the world. The cowpea utilizes serine peptidase inhibitors as a defense against herbivorous insects. Peptidases have been considered a target for pest control. The cowpea bruchid in turn employs cysteine peptidases as its major digestive peptidase to avoid the plant’s defense. Important …
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Dipeptidyl Peptidase-4 in Cariometabolic Disease
… expression of the serine protease dipeptidyl peptidase-4 (DPP4) were investigated in a series of murine models of metabolic dysfunction-associated steatotic liver disease (MASLD), cardiometabolic disease and myocardial infarction. In vivo experiments were conducted using several genetic …
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Structure Determination of Viscotoxin A1, Tendamistat and Tri Peptidyl peptidase-I
… der S53 Familie der sedolisinartigen Peptidasen sind. Im Gegensatz zu anderen S53 Peptidasen weist die TPP1 Struktur sterische Einschränkungen an der P4 Substrattasche auf, welche erklärt, weswegen TPP1 Tripeptide vorzugsweise vom unsubstituierten Aminoende her schneidet.
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Studies on cathepsin B of Eimeria tenella and pyroglutamyl peptidase of Leishmania major
A sequence encoding a cathepsin B-like cysteine peptidase of the clan CA, family C1 was identified in the genome database of E. tenella. The sequence corresponded to a single copy gene, and did not carry any introns. The E. tenella enzyme, sharing 42% identity with the Toxoplasma gondii toxopain-1, …
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Chromogenic detection of dipeptidyl peptidase IV (DPP-IV) activity using peptide-functionalized gold nanoparticles
… biosensing assay for detection of dipeptidyl peptidase IV (DPP-IV) enzyme activity using peptide functionalized gold nanoparticles. The distinctive optical and physical properties of gold nanoparticles (Au NP) were harnessed for the development of a colorimetric assay for rapid sensing of …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… as well as lysosomal, aspartic and cysteine peptidases. <br>To investigate the role of the lysosomal cysteine peptidase cathepsin B (CTSB) in tumour progression and metastasis, transgenic mice FVB/N-TgN(MMTVPyVT)634Mul, developing multifocal metastasising mammary carcinomas, were utilised. …
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Analysis of cathepsin H-deficient mice and identification of a dense cluster of placenta specific peptidase genes
… mice a cluster of placenta-specific cysteine peptidase genes was characterized on mouse chromosome 13. This study allowed further defining the map of placenta-specific cysteine peptidase genes and also allowed the identification, in the same cluster, of pseudogenes and of four genes encoding …
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Parallel effects of signal peptide hydrophobic core modifications on cotranslational translocation and posttranslational cleavage by purified signal peptidase
… post-translational cleavage by purified signal peptidase were observed. A model is proposed to explain these parallel effects.
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Hydrolysis and Toxicity of Aspartyl Peptides and the Influence of Metal Ions on Aspartyl Peptide Hydrolases in Salmonella Enterica Serovar Typhimurium
Extracts of a multiply peptidase deficient (MPD)(pepN,A,B,D,P,Q,T,E,iadA,iaaA ) Salmonella enterica serovar Typhimurium strain contain an aspartyl dipeptidase activity which is dependent on Mn2+. Purification of this activity followed by N-terminal sequencing of the protein suggested that the …
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The collagenolytic activity analysis of Geobacillus thermoleovorans DSM 15325 peptidases: characterization of M3 proteolytic enzymes family M3B subfamily oligopeptidase and U32 proteolytic enzymes family peptidase /
… in organisms. The diversity of collagenolytic peptidases from non-pathogenic bacteria remains only fragmentary characterized, whereas the characterization of the diversity of collagenolytic peptidases from eukaryotes and pathogenic bacteria are far more comprehensive. The determined …
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Functions of alternative ClpP subunits in Pseudomonas aeruginosa
… unfoldase stacked with a compartmentalized peptidase, are central to bacterial proteolysis, and use the energy of ATP hydrolysis to unfold and translocate protein substrates into the peptidase chamber for their destruction. The opportunistic pathogen Pseudomonas aeruginosa is unusual in that …
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A Characterization of Aspartyl Peptidases in Salmonella Typhimurium
Few of the peptidases previously characterized from Salmonella typhimurium are capable of hydrolyzing aspartyl peptides. Peptidase E, an aspartyl specific dipeptidase, was the first member of a new family of peptide hydrolases that now includes peptidases from other proteobacteria and from two …
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Studies on oligopeptidase B of Leishmania major
Peptidases of Leishmania are acknowledged virulence factors. It is hypothesised that peptidases are crucial for the survival of Leishmania in its hosts and that many could be potential targets for new antileishmanial drugs. As such, the investigation of peptidase activity in live Leishmania …
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Role of communication between subunits and enzymes in ClpXP-mediated substrate unfolding and degradation
… complexes and combines with the ClpP peptidase to form ClpXP, a molecular machine with structural and functional similarity to the eukaryotic 26S proteasome. ClpXP consists of hexameric ClpX rings stacked coaxially against the double-ring ClpP₁₄ peptidase. ClpXP's peptidase active …
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Archaeal signal peptides and cell surface structures
… Integral to this process are the various signal peptidases. Two types of archaeal signal peptidases are identified thus far: signal peptidase I (SPI) and the preflagellin peptidase. SPI is responsible for processing the majority of secreted proteins. Sequence analysis of archaeal SPI enzymes …
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The proteolytic activity of yoghurt and probiotic bacteria for the improved viability of probiotic bacteria in fermented milk products
… particularly their amino-, di-, tri- and endo-peptidase activities was studied. Nine strains of Streptococcus thermophilus, 6 strains of Lactobacillus delbrueckii ssp. bulgaricus, 14 strains of Lactobacillus acidophilus and 13 strains of Bifidobacterium ssp. were screened for proteolytic …
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Functional and structural studies of AAA+ proteases
… into an associated self-compartmentalized peptidase for degradation. In addition to participating in proteolysis, AAA+ ATPases, by themselves, can unfold and/or remodel macromolecular complexes. However, rigorous characterization of these unfolding reactions in the absence of proteolysis …
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Angiotensin II modulates glutamate-induced depolarizations and synaptic transmission in rat locus coeruleus neurons in vitro.
… AII was also found to be subject to rapid peptidase degradation. When AII was applied by bath perfusion, rather than by iontophoretic or pressure application, it had little or no effect on Glu responses. However, when Sar$\sp1$-AII, an analogue which is resistant to aminopeptidase …
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Structural Principles of Substrate Recognition and Unfolding by the ClpAP and ClpXP AAA+ Proteases
… hexameric AAA+ unfoldase and a compartmentalized peptidase. AAA+ proteases harness the energy of ATP hydrolysis to mechanically unfold and translocate substrates through the axial channel into the peptidase chamber for degradation. Degradation by AAA+ proteases is carefully regulated by several …
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Identifying the requirement and mechanism of the dynamic yet kinetically stable ClpXP interface
… control. To achieve these goals, a barrel-shaped peptidase, with active sites in a sequestered chamber, cooperates with an attached AAA+ hexamer that recognizes, unfolds and translocates the protein substrate into the degradation chamber. The interaction between the AAA+ hexamer and peptidase must …
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