Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"pentameric Ligand-Gated Ion Channels"”.
-
Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
Pentameric ligand-gated ion channels (pLGICs) are a superfamily of neurotransmitter-gated ion channels, that includes (in vertebrates) the nicotinic Acetylcholine Receptor (AChR), Serotonin Receptor type 3 (5-HT3R), γ-Aminobutyric acid Receptor type A (GABAAR), and the Glycine Receptor (GlyR). All …
-
The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels
The pentameric ligand gated ion channel super family plays a central role in fast synaptic communication between neurons and at the neuromuscular junction. Extensive studies on the prototypic pLGIC, the Torpedo nicotinic acetylcholine receptor (nAChR) have revealed an exquisite lipid sensitivity, …
-
Development and application of quantitative ligand-binding studies to elucidate mechanistic aspects of pentameric ligand-gated ion channels
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
-
Structure and Function of the Alpha3Beta4 Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that are essential for the proper function of the central and peripheral nervous systems. The α3β4 subtype is highly expressed in the autonomic ganglia, where it contributes to signal transduction from the central nervous …
-
A Structural and Computational Study of GABAA Receptor Diversity
GABAA receptors (GABAARs) are pentameric ligand-gated ion channels that modulate the activity of neural circuits in response to binding of the neurotransmitter $\gamma$-aminobutyric acid (GABA) or small molecule therapeutics, such as benzodiazepines or general anaesthetics. GABAARs assemble from a …
-
The emerging role of the a4(+)a4(-) interface as a determinant of functional signatures of a4ß2 nicotinic acetylcholine receptors
… agonist sensitivity. Being heteromeric pentameric ligand-gated ion channels (pLGIC), a4p2 receptors are activated by binding of agonist to sites located at the a4( + )/P2( -) interfaces. These interfaces are present in both stoichiometries they are unlikely to contain structural …
-
Understanding the Atomic-Scale Mechanisms of the Human [alpha]4[beta]2 Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels. These receptors are present in the central and peripheral nervous systems where they mediate fast synaptic transmission by allowing the flux of cations through the plasma membrane. The heteropentameric α4β2 subtype is the …
-
An investigation into the desensitization of neurotransmitter gated ion channels — functional relevance, impact on ganglionic receptor function, and structural insights
The desensitized state of neurotransmitter-gated ion channels (NGICs) remains poorly understand, both in terms of its functional role and its structure. Although the state was historically thought to have limited functional relevance, recent results have demonstrated that the state is indeed likely …
-
Structural insights into the GABAA receptor gating cycle
GABA<sub>A</sub> receptors are pentameric ligand-gated ion channels (pLGICs) that control multiple aspects of animal physiology, including the rapid inhibitory neurotransmission within the vertebrate central nervous system. They activate and desensitize in a few milliseconds, which is a crucial …
-
Mechanism of anaesthetic activation, combination and antagonism
… type A γ-aminobutyric acid receptors (GABAAR) – pentameric ligand gated ion channels (pLGICs) – are the main mediators of fast inhibitory neurotransmission in the human brain. Malfunctions in these receptors are a common cause for neurological disorders such as anxiety, epilepsy, schizophrenia …
-
The Lipid-Facing M4 Helix of α4β2 nACh and 5-HT3A Receptors
Pentameric ligand-gated ion channels (pLGICs) are expressed throughout the human nervous system, and contribute to a range of muscle, gut, and neurological functions. Elucidating their mechanism of action and how it might be modulated would improve our understanding of the nervous system, and …
-
Computational modeling and simulation of ligand-gated ion channels
The pentameric ligand-gated ion channel (pLGIC) superfamily, from bacteria to the brain, convert chemical signals into electric signals. These proteins are composed of two distinct domains; the extracellular domain (ECD), where the chemical compounds (ligands) bind, and the transmembrane domain …
-
The role of subunit interfaces in the function of (α4β2)2β2 nAChRs
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels formed from homologous subunits, of which there are many different subtypes. The ability to combine different types of subunits into an individual pentamer enables a wide diversity of functional properties to meet a …
-
Modulación molecular de la función del receptor neuronal α7
… entre sí. La sinapsis química es una unión funcional entre neuronas en la que el neurotransmisor liberado por una de ellas interactúa específicamente con proteínas de membrana de la otra, los receptores postsinápticos. Los receptores de la familia cys-loop, que incluye al receptor nicotínico de …
-
Σχεδιασμός, έκφραση και δομικές μελέτες τμημάτων του ανθρώπινου νευρωνικού νικοτινικού υποδοχέα ακετυλοχολίνης
Οι νικοτινικοί υποδοχείς ακετυλοχολίνης (nAChRs) ανήκουν στους υποδοχείς Cys-θηλιάς, που διαμεσολαβούν και ρυθμίζουν την ταχεία συναπτική νευροδιαβίβαση. Είναι πενταμερή κανάλια ιόντων που ενεργοποιούνται από προσδέτη και απαρτίζονται από πέντε ομόλογες υπομονάδες, καθεμία εκ των οποίων …