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Showing 1 to 15 of 15 for “"penicillin-binding proteins"”.
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The penicillin-binding proteins of Bacilli
A study of the penicillin-binding proteins (PBPs) in the membranes of various species of Bacilli by dodecylsulphate/polyacrylamide gel electrophoresis followed by detection of the PBPs by fluorography has shown the presence of 3-5 such proteins depending on the species. Labelling of growing cells …
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Requirements for Compartmentalization of Penicillin-Binding Proteins during Sporulation in Bacillus subtilis
Penicillin-binding proteins (PBP's) are membrane-associated enzymes involved in the polymerization of peptidoglycan. PBP's are divided into three classes based upon their molecular weights and functional domains. Gene expression is regulated in the two differentiated cells in Bacillus subtilis, the …
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Studies of the Class A High-Molecular Weight Penicillin-Binding Proteins in Bacillus subtilis
… element of the bacterial cell wall. These proteins, known as penicillin-binding proteins (PBPs), are identified through the presence of conserved motifs within their functional domains. The Class A high-molecular weight PBPs are bifunctional, performing the penicillin-sensitive …
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Investigation into the membrane interactive properties of the escherichia coli low molecular weight penicillin-binding proteins
… which could include low molecular mass penicillin-binding prpteins (PBPs). These proteins include PBP4, PBP5 and PBP6 which are penicillin sensitive enzymes associated with the periplasmic face of the inter membrane. The levels of these associations have been linked to enzymic activity …
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Effects of Protein Domains on Localization of Penicillin-Binding Proteins 2a and 2b in Bacillus Subtilis
… provides the cells with a defined morphology. Penicillin-binding proteins (PBPs) catalyze the polymerization of the peptidoglycan in Bacillus subtilis. PBP2a and PBP2b are class B PBPs which have been known to have transpeptidase activities and they localize at different positions on the cell …
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Enabling early stage drug discovery targeting high molecular mass penicillin-binding proteins in <i>Yersinia pestis</i>
… targets. The rationale for studying selected penicillin-binding proteins (PBPs) in Y. pestis and a general introduction to this family of proteins, the history of β-lactam antibiotics and the organism of interest are given in Chapter one. High molecular mass (HMM) PBPs are well-established …
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Myceloid cell formation in Arthrobacter globiformis during osmotic stress
… Since myceloid formation may result from altered penicillin-binding proteins (PBPs), PBP profiles of stressed and unstressed A. globiformis were studied. Eight PBPs were identified, ranging in molecular mass from 91,000 to 30,000 daltons. Myceloids appeared to lack PBP 2a (84 kD) and PBP 2b (82 …
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The Influence of ampC Expression and Penicillin Binding Protein Binding on the Variation of ß-lactam Induction Potential in Three Genera of Enterobacteriaceae
… carbapenems. The interaction of ß-lactams with penicillin binding proteins (PBPs) disrupts cell wall synthesis and in the case of some ß-lactams, initiates the ampC induction pathway. Several factors are involved in the induction of ampC in all genera including the interaction of a ß-lactam …
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Insights Into The Reactivation, Regulation and Essentiality of Oxidative Protein Folding Pathways In Actinobacteria
… folding, stability and function of exported proteins. The process of disulfide bond formation, termed oxidative protein folding, is catalyzed by thiol-disulfide oxidoreductase enzymes. Oxidative protein folding pathways influence processes essential for bacterial physiology and pathogenicity. …
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Functional Studies of Penicillin-binding Protein 1 in Bacillus subtilis
The penicillin-binding proteins (PBPs) synthesize and modify peptidoglycan (PG), the main structural element of the bacterial cell wall. PBPs and PG synthesis are highly conserved in all bacteria and both have been important targets for antibiotic and antibacterial development. In the Gram positive …
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Mode of Action of Penicillin in Pneumococci: From Inhibition of Cellular Targets to Bacterial Death
… inhibition of these targets (the membrane bound penicillin-binding proteins, or PBPs) leads to the irreversible antibacterial effects of these drugs have remained elusive. Treatment of Streptococcus pneumoniae with penicillin (or other cell wall inhibitors) results in a rapid sequence of events …
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Synthesis and Biological Studies of Lanthionine Derivatives
… as inhibitors or inactivators of resistant proteins like Penicillin Binding Proteins (PBPs) or to find new targets which allow putting peptidoglycan (PG) biosynthesis under control. The aim of this work is to develop a new labeling method for PG allowing to identify novel antibiotics and …
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Investigation into the membrane interaction of E.coli Pencillin binding protein 4
The low molecular mass penicillin-binding proteins (PBPs) of E. coli play a regulatory role in the terminal stages of peptidoglycan biosynthesis. PBPs 4, 5 and 6 have been shown to possess DD-carboxypeptidase activity with PBP4 also having an endopeptidase activity. PBP5 and 6 are proposed to …
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Characterization of two Bacillus subtilis penicillin-binding protein-coding genes, ykuA (pbpH) and yrrR (pbpI)
Penicillin-binding proteins (PBPs) are required in the synthesis of the cell wall of bacteria. In Bacillus subtilis, PBPs play important roles in the life cycle, including both vegetative growth and sporulation, and contribute to the formation of the different structures of vegetative cell wall and …
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Antibiotic Tolerance and Heteroresistance: Associated Fitness Costs and Potential in Evading Antibiotic Killing
… infection, beta-lactams- specifically, penicillin, which inhibit wall synthesis. We found that recombination with related viridans species via horizontal transfer may be preferable to de novo on-target mutations in penicillin-binding proteins in S. pneumoniae to acquire resistance more …