Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"penetration enhancer"”.
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QSAR modeling of chemical penetration enhancers using novel replacement algorithms
… are suitable to cross the skin barrier. Chemical Penetration Enhancers (CPEs) are used to promote the absorption of solutes across the dermal layers. In this investigation, a Quantitative Structure-Activity Relationship (QSAR) model is applied to relate chemical penetration enhancer structures …
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Chemical penetration enhancers and in situ-forming reservoirs for trans-tympanic drug delivery : progress toward improved treatment of Otitis media
… that includes potentially synergistic chemical penetration enhancer (CPE) combinations and an antimicrobial sufficiently increases antimicrobial flux such that therapeutic levels can traverse the tympanic membrane (TM) within 12 hours, in vitro. We compare excised chinchilla TMs treated with …
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New lipid nanovesicles as topical delivery sistems for ant-inflammatory drugs
… the first work concentrated and interconnected penetration enhancer containing vesicles (PEVs) are proposed as carriers for dermal delivery of diclofenac. PEVs were prepared by using a commercial phosphatidylcholine mixture (180 mg/m) and transcutol in different amounts. Conventional liposomes …
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EVALUATION OF PHARMACEUTICAL AND COSMETIC USE OF EXCIPIENTS OBTAINED FROM CITRUS PROCESSING WASTE PRODUCTS
… nanosystems were found to be effective skin penetration enhancer due to their ability to induce a conformational change in stratum corneum lipids, shifting them from an ordered configuration to a liquid-like organization upon penetration of BLCs. The hypothesis of perturbation of the stratum …
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Biopharmaceutic and Pharmacokinetic Evaluation of Hesperidin and Hesperetin for Ocular Delivery
… humor. Inclusion of benzalkonium chloride, as a penetration enhancer/preservative, significantly improved the vitreal levels of hesperetin. In conclusion, topical administration would be ideal for the delivery of hesperetin to the deeper ocular tissues. Development of a controlled release drug …
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Topical Formulation For Stimulating Sweat Secretion as an Alternative to Iontophoresis
… each at varying concentrations were screened as penetration enhancers. In vitro penetration test (IVPT) was performed on these formulations to compare the influence of these ingredients on the penetration of pilocarpine. The results from the preliminary studies indicate that the formulation with …
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Innovatives liposomes for overcoming biological barriers
In this thesis work were prepared and characterized liposomes and liposomes modified with a coating of chitosan called chitosomes. Through these structures were conveyed drugs of natural origin with anti-inflammatory and antioxidant properties: quercetin,phycocyanin and curcumin. The liposomes …
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Nanosized systems for efficient delivery of antitumoral and anti-inflammatory drugs
… obtained by the addition of a permeation enhancer, Transcutol (TRC), in the aqueous stabilizer solution and to study the effect of Transcutol on the transdermal permeation and skin accumulation of DCF nanocrystals. DCF-TRC-nanosuspensions, prepared using the wet media milling technique, …