Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"pegylated interferon"”.
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Heterogeneity of hepatitis C-virus in genotype 1 patients treated with the combination therapy of pegylated interferon and ribavirin
… improved. Today a combination therapy with pegylated interferon a (PEG-IFN) and ribavirin is recommended. The sustained virological response rate six months after stop of treatment (SVR) is about > 55% in treatment naive patients. Because the treatment with PEG-IFN plus ribavirin is 6 to 12 …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
… The current standard of care consists of pegylated interferon and ribavirin (RBV), a nucleoside analog. While RBV improves treatment outcome, and will likely be an important component of therapy with next-generation viral inhibitors, RBV’s mechanism is controversial. Most of RBV’s proposed …
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The Use of Healing Touch in Adults with Hepatitis C Virus Receiving Interferon and Ribavirin: A Pilot Study
… effective treatment for HCV is a combination of interferon and ribavirin; however, as many as 92% of patients experienced fatigue as a side effect. The severity of this symptom caused some patients to skip dosages or even stop the required medication regimen before it was completed. The primary …
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A Decade of Hepatitis C at the UCT/GSH Liver Clinic in the Pre-DAA era
… at Groote Schuur Hospital (GSH) in the Pegylated interferon (Peg-IFN) and Ribavirin (RBV) management era. Methods Patients with chronic HCV attending GSH Liver Clinic from 2002 to 2014, were included, in the analysis. Relevant data were extracted from a registry and existing clinical …
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Short interval change in hepatitis C hypervariable region 1 in chronic infection. Are there treatment windows in the envelope?
… in the United States. Dual treatment with pegylated interferon and ribavirin has until 2010 been the mainstay of treatment. The emergence of newer agents with direct activity against specific virus proteins has revolutionised HCV treatment but, the high cost of these medications are likely …
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Prognostic markers associated with tyrosine kinase inhibitor treatment response and maintenance of treatment free remission in chronic myeloid leukaemia
… Pinnacle, aims to study the combination of pegylated interferon and nilotinib in a similar context. Enrolment in this study is ongoing. The same prognostic marker (EMR) may identify patients unlikely to achieve deep molecular responses (DMR), a milestone associated with excellent long term …
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A study of immune responses during antiviral treatment for hepatitis C virus infection
… receptors and RIG-I by viral PAMPs to induce Interferons. HCV proteins also block signalling pathways initiated by endogenous interferon. Interferon stimulated genes induced despite these viral evasion mechanisms remain ineffective in viral clearance. These mechanisms lead to viral persistence …