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Showing 1 to 9 of 9 for “"pbp5"”.
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Etude de la régulation de l'expression de l'opéron ftsW-psr-pbp5 chez Enterococcus hirae
… et d’établir le rôle de l’opéron ftsWpsr-pbp5 chez Enterococcus hirae. La première partie de ce travail a été focalisée sur les protéines codées par les gènes ftsW, psr et pbp5. La publication du premier génome d’E. hirae ATCC9790 nous a permis d’identifier et situer dans le génome …
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Investigation into the membrane interactive properties of the escherichia coli low molecular weight penicillin-binding proteins
… prpteins (PBPs). These proteins include PBP4, PBP5 and PBP6 which are penicillin sensitive enzymes associated with the periplasmic face of the inter membrane. The levels of these associations have been linked to enzymic activity and elucidation of the mechanism(s) involved in these associations …
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Insights Into Determinants That Contribute to Colonization, Virulence and Antibiotic Resistance In Enterococci
… colonization. Last, I demonstrated that the <em>pbp5 </em>gene, part of the <em>E. faecium</em> core genome that shows sequence variation between the clades and encodes a penicillin binding protein important for β-lactam resistance, is differentially expressed between strains, with higher PBP5 …
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Molecular and Genomic Based Insights Into The Evolution of Enterococcus Faecium From Commensal to Hospital-Adapted Pathogen
… time in clinical strains. By sequencing the <em>pbp5</em> gene, I demonstrated an ~5% difference in the <em>pbp5 </em>gene between strains with MICs <4ug/ml and those with MICs >4µg/ml, but no specific sequence changes correlated with increases in MICs within the latter group. A 3-10% nucleotide …
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Requirements for Compartmentalization of Penicillin-Binding Proteins during Sporulation in Bacillus subtilis
… Analyses of a low molecular weight PBP, PBP5*, suggested that expressing dacB in either the mother cell or in the forespore could regulate the level of spore peptidoglycan cross-linking to what is typical of wild type spore peptidoglycan.
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Investigation into the membrane interaction of E.coli Pencillin binding protein 4
… with PBP4 also having an endopeptidase activity. PBP5 and 6 are proposed to anchor to the periplasmic face of the inner membrane via C-terminal ahelices whereas the association of PBP4 with the membrane is more ambiguous and may involve a specific binding site and/or C-terminal amphiphilic …
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Molecular Mechanisms of Antimicrobial Resistance In Multi-Drug Resistant Enterococci
… causes mislocalization of select PBPs, like Pbp5 which is essential for beta-lactam resistance, increasing their beta-lactam affinity. Select class A PBPs that likely retain functionality and compensate are hypersusceptible to cephalosporins, thus contributing to the seesaw effect. This study …
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The penicillin-binding proteins of Bacilli
… of PBPs 1, 3 and 4 of B. megaterium. PBP5 has also been purified by affinity chromatography and this purified protein catalyses a DD-carboxypeptidase reaction. None of the other purified PBPs has been shown to have enzymic activity in the terminal stages of peptidoglycan biosynthesis. …