Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"pazopanib"”.
-
Metabolic Factors Determining Outcome in Chemotherapy: Studies with Pazopanib
… animals. Using a novel anti-cancer agent pazopanib as a test substrate, the work detailed in this thesis assesses differences in the pharmacokinetic profile of pazopanib in various humanised and knock out animal models, as well as differences in toxicological responses. Furthermore, this …
-
Nanoparticles Targeting at Inflammation Site
… of hydrophobic therapeutics, with a focus on pazopanib. Addressing key challenges in drug solubility, stability, and scalable manufacturing, this work explores polymeric, lipid-based, and peptide-modified nanocarriers tailored for chronic disease applications. In the context of osteoarthritis …
-
Monitorización farmacoterapéutica de inhibidores de tirosina quinasa en pacientes oncológicos.
… administrados (erlotinib, imatinib, lapatinib, pazopanib, sorafenib y sunitinib) y las consecuentes modificaciones de dosis realizadas. Material y método: estudio analítico retrospectivo en el que se han incluido 74 pacientes en tratamiento con TKIs, a los que se les ha realizado TDM y …
-
Improved delivery of molecularly targeted agents upon modulation of multidrug resistance efflux proteins at mouse blood brain barrier
… small molecule tyrosine kinase inhibitors; pazopanib and vandetanib. In vitro and in vivo results showed that the entry across the BBB for these drugs is limited via active efflux. This could be a plausible mechanism for inefficacy seen for these drugs in clinical trials when used as …
-
Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
… novel pentablock (PB) copolymer nanoparticles of pazopanib for treatment of ocular neovascularization. Our results indicated that PB copolymer based drug delivery systems can serve as a platform technology for the development of sustained release therapy along with evasion of drug efflux for the …
-
Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
… effectively with LY, including erlotinib, pazopanib, anti-PD-L1 antibody, and the PAK1 inhibitor FRAX597, each demonstrating increased T cell-mediated cancer cell killing. Our co-culture model has proven to be an effective preclinical tool for screening immunotherapies, providing valuable …