Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 224 for “"payloads"”.
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Active vibration isolation for flexible payloads
Results are presented of an experimental and analytical investigation to determine the feasibility of using active control techniques to (1) attenuate the response of a flexible payload to low frequency sinusoidal vibration disturbances, (2) damp the transient response of a flexible payload to step …
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Methods for delivering liquid payloads from high altitudes
As part of a military design project, further research was requested into an optimum method for delivering water from high altitude to a civilian population on the ground. This thesis explores current airdrop technology as well as three proposed methods of delivering potable water at terminal …
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Adaptive Predictive Controllers for Agile Quadrupedal Locomotion with Unknown Payloads
… while tasked with transporting unknown payloads. In the first project, a novel hierarchical planning and control framework for robust payload transportation by quadrupedal robots is developed. This framework integrates an adaptive model predictive control (AMPC) algorithm with a …
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An analysis of multiple sensor system payloads for unmanned aerial vehicles
… and those equipped with multiple sensor system payloads. he measure of effectiveness used for this comparison is the time required by the UAV to search 100 percent of an assigned area. The physical and operating characteristics of available sensor systems are discussed in detail. We develop an …
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Energy-saving Trajectory And Control Design For Quadrotors With Slung Payloads
… and controllers for quadrotors with slung payloads.
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Flexure based mounts for sensitive payloads : a management and engineering study
With the cooperation of the Los Alamos National Laboratory and the Massachusetts Institute of Technology, an investigative and design study was performed to examine the history of the W80- 0 Area Aft Mount, understand its performance, and explore potential new designs. Simultaneously, professional …
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A lean safety review process for payloads on the International Space Station
… one of the activities that must be satisfied by payloads prior to flying. The goal of this study is to attempt to reduce the required resources needed to fly a payload on the Station. Using the MIT Lean Aerospace Initiative Transformation to Lean roadmap, three separate payload examples of …
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Precision Delivery of Multi-Scale Payloads to Tissue-Specific Targets in Plants
… principles to engineer the precise deployment of payloads in plants. Specifically, the thesis designs a novel silk-based biomaterial and fabricates a microneedle-like device capable of delivering a variety of payloads ranging from small molecules to large proteins into specific loci of various …
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Design, Development, and Testing of Research Payloads on Various Suborbital Flight-Test Platforms
… technique to characterize the behavior of payloads containing liquids in microgravity. Hands-on model rocketry has proven as a valuable research platform for subsequent payload deliveries.</p>
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Design and Validation of Hardware-in-the-Loop Testbed for Proximity Operations Payloads
<p>The research presented here is a new testbed design for CubeSat and payload testing and development. This research demonstrates a low-cost, hardware-in-the-loop testing apparatus for use with university CubeSat programs for testing throughout the different levels of the development process. The …
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Development of Extrachromosomal Genetic Technologies for Persistent and Tunable Expression of Therapeutic Payloads
… require sustained expression of therapeutic payloads, typically achieved through genomic integration of transgenic DNA via genome editing (e.g., CRISPR\Cas9) or integrating viral vectors (e.g., retrovirus, lentivirus). Integration-based approaches risk insertional mutagenesis and oncogene …
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Development of stapled peptide targeted covalent inhibitors and synthesis of novel ADC payloads for applications in cancer therapy
… the potential of the two molecules as payloads. Remarkably, the conjugates were found to have mid-pM cytotoxicity against antigen-expressing breast cancer cell lines and no appreciable activity against antigen-negative cancer cells.
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Design and synthesis of indole-based analogues of OXi8006 as inhibitors of tubulin polymerization and their incorporation as payloads in drug-linker constructs.
… These analogues were incorporated as payloads in drug-linker constructs featuring a valine-citrulline (Val-Cit) dipeptide linker for potential use in antibody-drug conjugates (ADCs). The goal is to facilitate selective payload delivery to the tumor microenvironment, where the linker …
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Nanosatellite Launch Data-Logger (Sync)
… delicate structures and optics into their payloads. These delicate payloads, however, may not survive the required absolute-worst-case launch vibration testing needed for flight certification. To help address this problem, and to better match testing conditions to real-world launch …
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Design and testing of a pan-tilt mechanism for severe environments
… gimbals. In current shipboard solutions the payloads are often placed on a platform above the gimbal drive train, which results in high moment loads on drive components during a wave impact. As the payloads grow in size, the moment grows as well, and the current gimbal design is insufficient …
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Synthesis and biological evaluation of structurally diverse indole-based analogues as inhibitors of tubulin polymerization and synthesis of drug-linker constructs cleavable by enzymes present in the tumor microenvironment.
… agents and VDAs offer promise as next generation payloads. Further selective targeting is provided by betabodies, which are engineered proteins that selectively target accessible phosphatidylserine (PS). Two small-molecule dual-mechanism payloads, KGP18 and KGP156, were synthetically tethered to …
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The dynamics of tethers and space-webs
… and while deploying and retracting symmetric payloads. The MMET system is used as a basis for examining the stability of space-webs using a triangular structure of tethers while rotating. The motion of small robots is introduced as they move on the space-web, and their motions are found to …
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Satellite System Safety Analysis Using STPA
… with relatively-decoupled, unique mission payloads, a template for future satellite STPA safety analyses was developed. The template seeks to aid and guide new STPA applications while reducing analysis time by providing the STPA analysis for many common satellite functions. Increasing …
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Optimized Peptide Nanomaterials as Delivery Vehicles for Hydrophobic Metal-Based Anticancer Agents
… as delivery vehicles for metal-based hydrophobic payloads. The tunability of the system is highlighted as well as the increase in cytotoxicity and selectivity in vitro. The rapid degradation of peptides in cell media may lead to the formation of new peptide-drug bioconjugates with increased …
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