Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"pattern recognition receptor"”.
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
… cells. These macrophages may sense alginate via pattern recognition receptors (PRRs), such as toll-like receptors (TLRs) and NOD-like receptors (NLRs). However, which PRRs are involved, how they recognize alginate, and whether alginate material characteristics and compositions can elicit …
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Identification and Characterization of LYSMD3, A Novel Epithelial Cell Pattern Recognition Receptor for Chitin
… disorders such as asthma. However, chitin recognition by mammals remains enigmatic at best. The principal receptor(s) on epithelial cells for chitin recognition remain to be determined. In this study, we demonstrate that LYSMD3 is expressed on the surface of human airway epithelial cells. …
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The Function of PTPN22 and the Autoimmune Risk Variant LypW in Immune Responses to Vaccination
… (Lyp), which regulates lymphocyte antigen receptor and Pattern Recognition Receptor (PRR) signaling. A PTPN22 variant R620W (LypW) predisposes to autoimmune and infectious disease, and confers altered signaling through antigen receptors and PRRs. We tested the hypothesis that LypW-bearing …
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STRUCTURAL AND FUNCTIONAL DETERMINANTS OF CASPASE-11 INFLAMMASOME ASSEMBLY DURING INNATE IMMUNE DEFENSE
Caspase-11 (Casp11) is a pattern-recognition receptor that senses cytosolic LPS. In response to binding cytosolic LPS, Casp11 assembles into a supramolecular organizing center (SMOC) designated the noncanonical inflammasome, where it is thought to undergo proximity-induced autoprocessing and become …
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DEVELOPMENT OF PROTEIN-BASED ANTIFUNGALS
… aims to explore the relationship between the Pattern Recognition Receptor Dectin1 used by immune cells to recognize the Pathogen Associated Molecular Pattern β-glucan to develop Dectin-1 based biopharmaceuticals against the common fungal pathogen Candida albicans as a model for the use of …
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Pam2ODN-Induced Epithelial Resistance Against Influenza A Requires STAT3 Activation
… treatment with a specific dyad of synthetic pattern recognition receptor (PRR) agonists, Pam2CSK4 and ODN M362 (referred to as “Pam2ODN”), can reduce the pathogen burden and improve mouse survival of pneumonia challenges. We have shown that protection against bacterial pathogens requires …
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Chemotactic and inflammatory responses to and recognition of Encephalitozoon spp. of microsporidia
… infiltration. Finally, investigations into the receptors involved in initiating host recognition and regulating chemokine production were examined. Toll-like receptor (TLR) 2 was shown to be activated by Encephalitozoon spores. Using siRNA gene knock-downs in MDM, TLR2 was revealed to activate …
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Understanding The Role Of Pentraxin 3 In Adipose Tissue Inflammation And Aging
… developed during obesity and aging. As a soluble pattern recognition receptor, Pentraxin 3 (PTX3) plays a vital role in innate immunity and can be induced by inflammatory stimuli in adipose tissue and adipocyte. Altered PTX3 levels have been observed in adipose tissue and blood during obesity and …
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Novel Immune-Regulatory Mechanisms in a Mouse Model of Traumatic Brain Injury
… discovering a novel role for the tyrosine kinase receptor EphA4 in the peripheral-derived immune response to brain trauma. Previous work has demonstrated significant differences in recovery from TBI in young vs adult animals, and some studies have indicated that the immune response contributes to …
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The Role of STING-Mediated Neuroinflammation in Traumatic Brain Injury
… it is available to bind cGAS, a cytosolic pattern recognition receptor. To determine whether brain-resident or peripheral immune cells are responsible for detrimental cGAS-STING signaling after TBI, we utilized bone marrow chimeric animals lacking STING in either the brain or hematopoietic …
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Exploring the Pharmacology of (+)-Naltrexone on Alcohol Reward and Anxiety Behaviours
… system, specifically, an innate immune receptor (Tolllike receptor 4) in mediating these phenomena. Toll-like receptor 4 (TLR4) is a pattern recognition receptor that detects conserved molecular epitopes expressed on pathogens, danger molecules and drugs of abuse. In response to alcohol …
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Expanding inducible epithelial resistance against pneumonia: novel virus, novel receptor
… We achieve this using a combination of pattern recognition receptor agonists – Pam2CSK4 and ODN M362 being the current formulation – which produce synergistic levels of pathogen reduction and protection in our models. Recent endeavors by members of our lab have sought to identify and …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… cells. In parallel, stromal cells activate Notch receptor 3 (NOTCH3) on BrCa cells and STAT1 amplifies NOTCH3 transcriptional responses to expand therapy-resistant tumor-initiating cells. Stroma-mediated resistance is abrogated by combining radiation with gamma secretase inhibitors. Thus, stromal …
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Targeting toll-like receptor 4 related inflammation using small molecule, TAK-242, to attenuate inflammatory damage in pancreatitis and islet transplantation.
… during type 1 or type 3c diabetes. Toll-like receptor 4, a pattern recognition receptor found on various immune, endothelial, and epithelial cells, can respond to both endogenous and exogenous ligands resulting in enhanced cytokine and chemokine production as well as immune infiltration and …
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Exploring the Effects of Adjuvant Selection on a Novel Polyvalent Staphylococcus aureus Vaccine
… pilot study exploring the addition of different pattern recognition receptor agonists combined with the adjuvant AdjuPhos. The addition of toll-like receptor 2 (TLR2)-containing agonists enhanced S. aureus clearance, and consequently, further cellular studies were undertaken with a novel TLR2 …
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lncRNA RPPH1 in melanoma: novel functions as cargo of tumor-derived Extracellular Vesicles
… interferon-mediated immune responses through Pattern Recognition Receptor (PRR) signalling pathways. Notably, the injection of melanoma-derived EVs or synthetic RPPH1 into healthy zebrafish larvae induces sterile inflammation, consistent with the activation of PRR-dependent signalling in …
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The Genetic, Molecular, And Cellular Bases Of Unidentified Primary Immunodeficiencies
… From cell intrinsic mechanisms of pathogen recognition to multi-cellular interactions over vast ranges of time and space, the immune system is both essential for protection from infection and central to the pathogenesis of many diseases. Thus understanding it has long been a focus of …
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Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
… and genomics by focusing on the regulation patterns of glycosyltransferase (GT) genes in breast cancer cell line following the treatment with a large set of Food and Drug Administration (FDA) approved drugs. This is based on the understanding that aberrant glycosylation in breast cancer …
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Characterization of pro- and anti-inflammatory immune responses in SARS-CoV-2 infection
… brewing infection. This response begins through recognition of pathogen-associated molecular patterns (PAMPs) from the virus, or from other signatures characteristic of tissue damage, damage-associated molecular patterns (DAMPs), by pattern recognition receptors (PRRs) that in turn stimulate …
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Development of an Autologous Human Dendritic Cell Vaccine against Mycobacterium tuberculosis in Patients with Extensively Drug-Resistant Tuberculosis
… with a differential combination of cytokines and pattern-recognition receptor agonists (maturation cocktail) together with different TB antigen combinations. The complete cocktail contained interferon-, interferon-, CD40L, IL-1 and TLR-3, TLR-7 and TLR-8 agonists, whilst in the limited …
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