Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"patient-derived xenograft"”.
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… to prevent metastatic cancer. We used a set of patient-derived xenograft mouse models of melanoma, in which the metastatic potential of individual tumor lines correlated strongly with the history of metastasis in the patient donors. Six tumor lines with low metastatic potential (L-met) and nine …
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Patient-derived and xenograft-derived organoids for characterization, drugs testing and biobanking of pediatric brain tumors
… tumor, have a higher incidence in younger patients, whereas older ones tend to present tumors of glial origin. Most of CNS-embryonal tumors are highly malignant and consequently leading to poor prognoses. Despite the understanding of the underlying molecular landscape of these tumors that …
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Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma
… and characterise novel models of UPS from patient-derived xenograft models, (ii) identify compounds and target classes efficacious in UPS, and (iii) explore the anti-cancer effects of lead compounds, using the models developed. The discovery of new therapeutic options for UPS has been …
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Oncolytic viruses enhance long-term NK cell anti-tumor cytotoxicity through AP-1 and IRF pathway activation
… receptors and cytotoxicity markers. In a patient-derived xenograft glioblastoma mouse model, the combination of NK cells and Delta-24-RGD significantly extended mouse survival compared with monotherapy, underscoring the therapeutic potential of this approach. Mechanistically, enhanced NK …
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Investigating the Mechanisms of Resistance to Dual PI3K/MTOR Inhibitor in PIK3CA Mutant Basal Like Bladder Cancer
… to targeted therapies and thereby provide patients with maximal clinical benefit. Using two MIBC patient derived xenograft models (PDX) that carry alterations in PI3K signaling, one of the most dysregulated signaling pathways in bladder cancer, we studied determinants of response to PI3K …
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Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… States. Although KRAS is mutated in 50% of patients with metastatic CRC (mCRC), it has historically been a challenging therapeutic target. The recent approval of novel covalent inhibitors selective for KRASG12C mutation have entered the clinic, which has not only marked a major milestone in …
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Exploiting p53 mutation in colorectal cancer: clinical positioning of Cdc7 inhibitors
… combination with chemotherapy. Analyses of a CRC patient-derived xenograft study were performed alongside in-vitro mechanistic studies of LY3143921. To further enhance the therapeutic potential of Cdc7i, in-vitro analyses of LY3143921 in combination with current standard of care systemic …
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APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA
… have seen tremendous improvement in cancer patient survival because of development of targeted therapies. In neuroblastoma, a common childhood cancer, approval of anti-GD2 immune therapy has improved patient survival and discovery of anaplastic lymphoma kinase (ALK) receptor activating …
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Hijacking Cancer Signaling: First-in-class JPRK-targeting Ligands for Fibrolamellar Hepatocellular Carcinoma
… and >500-fold selective drug candidates in patient derived xenografts. Fibrolamellar hepatocellular carcinoma is a rare un-treated liver cancer driven by a fusion kinase known as JPRK, a mutant of protein kinase A (PKA). Targeting this fusion kinase selectively is challenging due to the …
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Allogeneic Double Negative T cell Therapy as a Novel Treatment for AML Patients
… curative treatment for high-risk leukemia patients. However, a high disease relapse rate caused by residual disease and an associated toxicity such as graft-vs.-host disease (GvHD) remain as major issues that hamper recipients' survival. Many forms of immunosuppressants to control GvHD …
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First-order statistical speckle models improve robustness and reproducibility of contrast-enhanced ultrasound perfusion estimates
… image. The technique was then applied to a rapid patient-derived xenograft (PDX) model of renal cell carcinoma (RCC) in the chorioallantoic membrane (CAM) of chicken embryos. The ultimate goal of the PDX model is to screen RCC patients for de novo sunitinib resistance. The analysis of the …
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Targeting Autophagy to Improve Efficacy of Cdk4/6 Inhibition In Breast Cancer
… of reliable biomarkers to identify responsive patients and iii) acquired resistance to CDK4/6 inhibitors. Previous <em>in vitro</em> studies have shown that palbociclib mediated CDK4/6 inhibition induces G1 arrest and senescence in ER+ breast cancer cells, and a recent study in fibroblasts …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
… death worldwide. Outcomes are poor for patients with recurrent, advanced or metastatic NSCLC. Polo-like kinase 1 (PLK1), involved in the regulation of mitotic processes and the response to DNA damage, is overexpressed in NSCLC. Inhibiting PLK1 may be an effective treatment for NSCLC …
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Cd47+ Exosomes Facilitate Effective Targeting of Oncogenic Kras In Pancreatic Cancer
… the current standard of care, the prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) remains dismal. Genetic analyses of PDAC show that mutations in the GTPase KRAS are encountered in the majority of patients that present with the disease, and are key drivers of cancer …
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Simultaneous Targeting of CDK4/6 and BETs is Independent of RB Status in Osteosarcoma
… both treatment-naïve and previously treated OS patient-derived xenograft models. In a lung-metastatic OS model, CDK4/6i alone markedly reduced metastatic burden; however, at the tested BETi exposure, the addition of BETi did not further decrease metastatic foci. These results underscore the …
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Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs: Pharmacological Evaluation in Phenotypically Diverse Breast Cancer Models and Pharmacokinetic Assessment in Liver Microsome and Female Mouse Models
… tamoxifen-resistant (TamR) MCF-7 cells and patient-derived xenograft triple-negative BC cells (TU-BcX-4IC) as well as for potential mechanisms of action using selective MEK1/2, MEK5, and PI3K inhibitors. C4 and C5 inhibited TamR MCF-7 cells with equal potency and efficacy and both C4 and C5 …
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Multiplexed angiogenic biomarker quantification on single cells
… on other angiogenic receptors, such as platelet derived growth factor receptors (PDGFRs), Tie receptors, are also necessary for the development of an accurate angiogenesis model. To gain insights on the involvement of these angiogenic receptors in angiogenesis, I develop a method to quantify …
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Investigating the Genomics and Heterogeneity of Childhood Non-Hodgkin Lymphoma
… high-intensity chemotherapy. Unfortunately, many patients who relapse have a dismal prognosis, with long-term survival less than 30% for relapsed BL patients in particular. Furthermore, the side effects of chemotherapy on children are often severe, rendering intensive chemotherapy infeasible in …
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Investigating heterogeneity and mechanisms of resistance in paediatric B-cell non-Hodgkin lymphoma
… alone accounting for 38% of NHL diagnoses in patients under 15 years. Outcomes have improved significantly in recent years with the introduction of intensive multi-agent chemotherapy, followed by the addition of Rituximab, resulting in a survival rate exceeding 90%. Despite this, those …
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SYNTHETIC DOSAGE LETHAL INTERACTIONS OF POLO-LIKE KINASE 1 AND THEIR APPLICATION IN CANCER THERAPEUTICS
… combination of available databases with data on patient tumour gene expression and survival and gene essentiality in cell lines narrowed the list of polo-like kinase 1 synthetic dosage lethal hits to 105. These 105 genes were extensively experimental validated by using a robust set of different …
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