Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"patient prognosis"”.
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Local Estimation of Patient Prognosis
Statistical methods that can provide patients and their healthcare providers with individual predictions are needed so that informed medical decisions can be made. Ideally an individual prediction would display the full range of possible outcomes (full predictive distribution), would be obtained …
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MRI Radiomics Modeling and Survival Prediction of Pancreatic Ductal Adenocarcinoma Patients
… clinical and image-based, may be used to improve patient prognosis after diagnosis of this disease.Quantitative imaging analysis, namely radiomics, has been gaining popularity in medicine over recent years in identifying cancer variants that are particularly difficult to diagnose when symptoms are …
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Treatment Response Prediction in Acute Myeloid Leukemia Patients
Predicting acute myeloid leukemia (AML) patient treatment response has the potential to impact clinical decisions. A prediction given at the time of diagnosis for treatment response can assist physicians in making effective treatment decisions and improving patient prognosis. This project aimed to …
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Role of Lymphocyte Populations Following Allogeneic Haematopoietic Stem Cell Transplantation // Роля на лимфоцитните популации след алогенна трансплантация на хемопоетични стволови клетки
… process, which has critical importance for patient prognosis. Lymphocyte subpopulations play a key role in the immune regulation of recipients, and an imbalance in their number and function can lead to severe consequences – GVHD, relapse of the underlying disease, infectious and …
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TO INVESTIGATE THE ROLE OF RNF8 IN REGULATING MITOTIC PROGRESSION IN GLIOMAS
… Indeed, low RNF8 expression portends poor patient prognosis in glioma patients. Importantly, our mechanistic findings led to the rational combination of PLK1 and HSP90 inhibitors that elicit an additive effect in reducing GSC proliferation and stemness. Thus, our study has unveiled a novel …
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Decoding the RNA cargo of plasma-derived extracellular vesicles in metastatic castration-resistant prostate cancer
… castration-resistant prostate cancer (mCRPC) patients, treated with Enzalutamide in a chemo-naïve setting. Specifically, it incorporates EV physical characterization, EV-RNA and matched cfDNA genomics. The use of total RNA sequencing (RNA-seq) enabled the detection of both coding and …
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The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
… burden of anaemia among Hodgkin Lymphoma (HL) patients, data evaluating red cell concentrate transfusion is limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line ABVD treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39.5% and …
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Delineating metastasis in MSS colorectal cancer by single - cell RNA sequencing
… insights into drug development to improve patient prognosis.</p>
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The relationship between BRAF genetic alterations and the risk of tumour recurrence in Pilocytic Astrocytomas in children diagnosed at Red Cross Children's Hospital over a 33-year period
… reports on the impact of specific mutations on patient prognosis are controversial. 5–8 Advances in molecular techniques have opened the door for further studies to determine the relationship between these BRAF alterations (point mutations and gene fusions) and the risk of tumour recurrence. …
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Förster Resonance Energy Transfer-Based Quantification of D-2-Hydroxyglutarate & Locked Nucleic Acid Loop-Mediated Isothermal Amplification Mediated Detection of IDH1-R132 Single Nucleotide Variants in Glioma
… gliomas which provides valuable information on patient prognosis and treatment. Targeted therapies including maximal surgical resection and pharmaceutical mutant IDH inhibitors offer life extending benefits; however, currently implemented assays for the detection of <em>IDH1</em> mutations do …
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Predicting mortality for patients in critical care : a univariate flagging approach
Predicting outcomes for critically ill patients is a topic of considerable interest. The most widely used models utilize data from early in a patient's stay to predict risk of death. While research has shown that use of daily information, including trends in key variables, can improve predictions …
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Endosomal Trafficking and Exosomal Secretion of Egfrviii
… (GBM) tumors and is associated with poor patient prognosis. Persistent signaling due to a lack of the EGFR ectodomain and inefficient degradation have been suggested to underlie the tumorgenic properties of EGFRvIII. I observed that, like the parental EGFR, EGFRvIII is internalized into …
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Novel Regulation of the Cell Cycle During Cell Fate Decisions in the Central Nervous System
… of the SPDYA gene loci correlates with poor patient prognosis. We show that Spy1 is expressed at high levels in neurogenic regions of the adult brain and the overexpression of Spy1 significantly increases cell proliferation parameters including the number and longevity of neurospheres. These …
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Characterisation of the Helix pomatia agglutinin binding glycoproteins of colorectal cancer cell lines and tissue samples
… both as targets and as a means of predicting patient prognosis. The lectin from the Roman snail Helix pomatia (HPA) has attracted interest as tool for the detection of metastatic colorectal cancer but the HPA binding partners have remained poorly characterised. We established an in vitro model …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… is correlated with cancer development and patient prognosis, and is used clinically in disease surveillance. However, patients with non-alcoholic fatty liver disease (NAFLD) and lipid-droplet-filled hepatocytes can develop cancer in non-cirrhotic, relatively soft tissue. Given the clear …
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Sex Differences in Collateral Remodeling Following Hindlimb Arterial Occlusion
… limb ischemia in women, as well as worse prognosis and decreased survival post myocardial infarction. Therefore, understanding the possible differences in underlying vascular compensation mechanisms is crucial. With arterial occlusions, necrosis and tissue injury can be naturally mitigated …
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The Role of Epigenetics in Hereditary Colorectal Cancer Tumorigenesis: Validation of Genome-Wide Methylation Array Results through Bisulfite Sequencing
… biomarkers for early diagnosis and improved patient prognosis.
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A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk
… occurrence of tumor progression and predicts patient prognosis as well as survival. Invasion can be regulated by the Met receptor tyrosine kinase (c-Met), integrin beta4, and the lipid enzyme, 12-Lipoxygenase (12-LOX). Therefore we sought to determine if beta4, c-MET and 12-LOX comprise a …
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Differential Pax5 Levels Promote Mcl Dispersal and Progression and Predict A Poor Prognosis In Advanced Mcl Patients
… aggressive B cell cancers. PAX5 levels in MCL patients were significantly repressed compared to normal B cells. Surprisingly, we found there were quantitative differences in PAX5 expression levels within MCL patient tissues, which prompted us to silence PAX5 in MCL cell lines to characterize …
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