Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"pathway perturbation"”.
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Using pathway correlation profiles for understanding pathway perturbation
Identifying perturbed or dysregulated pathways is critical to understanding the biological processes that change within an experiment. Previous methods identified important pathways that are significantly enriched among differentially expressed genes; however, these methods cannot account for …
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Systems View Of The Soybean Genetic Mechanisms Involved In The Response To Plant Pathogen Infection
… large RIL population.The well studied metabolic pathways from the model plant Arabidopsis thaliana, were reconstructed in G. max based on sequence similarity comparison between the genomes of the two species. We performed algorithmic analysis of pathways in our set of soybean lines and RILs using …
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Action potentials as indicators of metabolic perturbations for temporal proteomic analysis
… explore how a compound interferes with specific pathways. However, these tools lack the potential to chronically monitor the time dependent temporal changes in complex biochemical networks, thus limiting our ability to identify possible secondary signaling pathways that could lead to potential …
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Identification and Characterization of the TGFβ/Hippo Crosstalk through Mathematical Modeling
… and homeostatic processes. The Hippo pathway is a major regulator of tissue growth and organ size. Hippo and TGFβ pathways are intimately interconnected. Hippo pathway mediators Taz/Yap interact with the TGFβ regulated Smads and when Hippo is activated, the cytoplasmically localized …
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Automatic Reconstruction of the Building Blocks of Molecular Interaction Networks
… the most-perturbed subgraph of a curated pathway of molecular interactions in a disease state. Our method is based on a novel score for pathway perturbation that incorporates both differential gene expression and the interaction structure of the pathway. We apply our method to a compendium …