Global ETD Search
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Showing 1 to 6 of 6 for “"pathway databases"”.
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PathMeld: A Methodology for The Unification of Metabolic Pathway Databases
A biological pathway database is a database that describes biochemical pathways, reactions, enzymes that catalyze the reactions, and the substrates that participate in these reactions. A pathway genome database (PGDB) integrates pathway information with information about the complete genome of …
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Identification of glucocorticoid-regulated genes and inferring their network focused on the glucocorticoid receptor in childhood leukaemia, based on microarray data and pathway databases
… or similar function and sharing networks and pathways. Four emergent clustering methods are used: Self organising maps (SOM), Emergent self organising maps (ESOM), the Short Time series Expression Miner (STEM) and Fuzzy clustering by Local Approximation of MEmbership (FLAME). These genes are …
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Data-driven and Machine Learning approaches for exploration and inference of Biological Pathways in physiological and pathological states
… dynamic cellular interaction network. Biological pathways are used in an attempt to model this network. These pathways play a key role in advancing our understanding of cellular processes and are employed across a wide range of tasks. The utility of pathways is demonstrated in the first part of …
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Annotating Human Interactome to Predict Pathways and Systematically Analyzing Network Rewiring in Cancer across Multiple Tissues
… about tissue- or disease-specificity. Pathway databases provide more detail about these conditions, but they cover only fraction of the proteome. The main goal of this dissertation was to annotate interactome through integrative computational methods and use these annotations, to …
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SEA: a novel computational and GUI software pipeline for detecting activated biological sub-pathways
… and succinctly analyze their data. Furthermore, pathway databases have grown increasingly robust with the KEGG database at the forefront. Previous tools have color-coded the genes on different pathways using differential expression analysis. Unfortunately, they do not adequately capture the …
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Enhanced evaluation of RNA expression in Esophageal Cancer tissues: Combining Microarray and RNA-Sequence approaches
… through distinct biological and epidemiological pathways, yet both are associated with poor prognoses. Barrett’s esophagus1 (BE), a metaplastic transformation of the normal oesophageal epithelium driven primarily by chronic gastroesophageal reflux, is a recognised precursor lesion for EAC. …