Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 728 for “"pathophysiology"”.
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Lymphatic pathophysiology of tumors
Lymph node metastases have a negative impact on cancer survival, but the mechanisms for lymphatic metastasis are not well understood. The universal finding in solid tumors of an absence of functional lymphatic vessels seems paradoxical, as cancer cells do travel through lymphatics in order to …
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Two investigations in molecular pathophysiology
This thesis is in two discrete parts. The first part deals with the mechanism of auto-stimulatory growth in the pathogenesis of malignant neoplasia. Experiments were undertaken to investigate the question of whether antagonism of growth-factor activity can lead to the death of the cells of a murine …
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The pathophysiology of spinal muscular atrophy
This thesis examines the disease course and pathophysiology of motor dysfunction in spinal muscular atrophy (SMA) using clinical, epidemiological, neurophysiological and genetic studies. Natural history studies confirmed the unique clinical course, atypical for a neurodegenerative disease, in which …
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Primary Aldosteronism: from pathophysiology to surgery
Contains fulltext : 320198.pdf (Publisher’s version ) (Open Access)
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TorsinA and the Pathophysiology of DYT1 Dystonia
<p>The goal of my dissertation work was to examine the systems biology of torsinA, a DYT1 dystonia-associated protein, by using rodent model systems. TorsinA is a putative ATPase associated with a variety of cellular activities (AAA+). Deletion of glutamic acid residue 302/303 in <em>TOR1A</em> is …
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NUTRITIONAL ASPECTS OF MUSCULOSKELETAL PATHOPHYSIOLOGY: FOCUS ON MAGNESIUM
Il magnesio (Mg), nella sua forma biologicamente attiva di catione, è un micronutriente essenziale per la vita. Circa il 25% del Mg totale dell’organismo si trova nel muscolo scheletrico, dove è fondamentale per il rilassamento delle fibre. Una corretta assunzione di Mg con la dieta è associata …
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Dengue virus infection. Clinical assessment, pathophysiology and management.
Contains fulltext : 49261.pdf (Publisher’s version ) (Open Access)
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Studies on the pathophysiology of gynaecological endocrine disorders
The functional organisation of the hypothalamic-pituitaryovarian axis is reviewed.
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Endothelin system in human cardiovascular physiology and pathophysiology
The experiments presented here arose from an interest in endothelial function and, particularly, a wish to better understand the pharmacology and physiology of the endothelin (ET) system in human blood vessels in health, and the influence of cardiovascular disease on the ET system. This work …
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Emerging concepts in the pathophysiology of acute pancreatitis
There is no specific treatment for acute pancreatitis (AP) reflecting an incomplete understanding of the critical pathophysiological factors that determine severity, drive multiple organ dysfunction (MODS) and cause the high mortality. New treatment paradigms are needed, and this thesis explores …
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Duodenal pH : new aspects of physiology and pathophysiology
… study reveals new aspects in the physiology and pathophysiology of the duodenal bulb pH.
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Red blood cell pathophysiology : comparative and diagnostic aspects
Captive black rhinoceroses in the United States are threatened by three major clinical disorders. Among these, haemolytic anaemia ranks as the number one cause of death. The object of this study therefore was to determine the metabolic lesion responsible for the haemolytic anaemia. Since black …
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Cytoskeletal Remodeling in Fibrous Environments to Study Pathophysiology
… matrix (ECM) is now known to be critical in pathophysiology. For example, during cancer progression, while uncontrollable cell division leads to tumor formation, the subsequent metastatic migration of cells from the primary tumor site to distant parts of the body causes most cancer-related …
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PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR IN BLEEDING AND THROMBOSIS
von Willebrand factor (VWF) is a multimeric glycoprotein mainly known to be involved in primary hemostasis recruiting platelets at the site of damaged vessels and acting as factor VIII (FVIII) carrier. Quantitative or qualitative alteration of VWF protein is responsible for von Willebrand disease …
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Roles of NF-kB in spinal cord injury pathophysiology
The pathophysiology of spinal cord injury (SCI) is characterized by multiple locomotor and sensory deficits, as well as chronic pain arising partly from significant cell loss at and around the injury site. Implicated in multiple biochemical pathways affected after SCI is the transcription factor …
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Blood-CNS transport mechanisms in pathophysiology and drug delivery
The blood-CNS barriers form a highly selective biological firewall; regulating the<br/>passage of solutes between the blood and cerebral microenvironment. This thesis<br/>modelled the blood-CNS barriers in vivo to determine the transport of nutrients,<br/>metabolic products and drugs across these …
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The pathophysiology of heart failure with preserved ejection fraction
Our studies demonstrate that patients with HfpEF have impaired myocardial energetics as indicated by the diminished in vivo myocardial PCr/ATP ratio. Data acquired during semi-supine cycling exercise indicates that patients with HfpEF had a dynamic impairment of LV active relaxation. In addition, …
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