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Showing 1 to 20 of 45 for “"pathogenicity island"”.
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Regulation of the Salmonella Pathogenicity Island 1 Type Three Secretion System
… Secretion System (T3SS) encoded on Salmonella pathogenicity island 1 (SPI1). The SPI1 TTSS injects effector proteins into the cytosol of host cells where they promote actin rearrangement and engulfment of the bacteria. HilC, HilD, and RtsA activate expression of SPI1 genes by binding upstream …
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Acquisition and Exclusion of Pathogenicity Island 1 (PAPI-1) in Pseudomonas Aeruginosa
… and adaptation. Conjugative transfer of genomic islands (GIs) has recently been reported in the opportunistic pathogen Pseudomonas aeruginosa. PAPI-1, one of the largest pathogenicity islands of P. aeruginosa, encodes several putative virulence genes and a major regulator of biofilm formation and …
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Role of Salmonella enterica subspecies enterica serovar Enteritidis pathogenicity island-2 in chickens
… cause of salmonellosis in humans. Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2) each encode a specialized type III secretion system (T3SS) that enables Salmonella to manipulate host cells at various stages of the invasion/infection process. The SPI-2 T3SS has been identified as …
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Die Bedeutung der "High-Pathogenicity Island" (HPI) für kommensale und uropathogene Escherichia coli
… die Bedeutung der genomischen Yersinia-"High-Pathogenicity Island" (HPI) für kommensale und uropathogene Escherichia coli dargestellt werden. Im Infektionsmodell der Maus wurde der Einfluss der HPI auf die Kolonisierungsfähigkeit des darmkommensalen E. coli Stamm Nissle Mutaflor® im Vergleich …
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Regulation of Salmonella pathogenicity island I through the hilD mRNA 3' untranslated region
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Integration of small RNAs in the control of Salmonella pathogenicity island 1(SPI1)
… Secretion System (T3SS) encoded on Salmonella pathogenicity island 1 (SPI1). The SPI1 T3SS directly injects several effector proteins into host cytosols, resulting in host actin rearrangement and engulfment of the bacteria. HilA activates transcription of the SPI1 structural components and …
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Helper phage capsid size redirection by staphylococcal pathogenicity island SaPI1 involves internal scaffolding proteins.
Staphylococcus aureus is one of the leading causes of nosocomial and community acquired infections. Many of the virulence factors are encoded on staphylococcal mobile genetic elements. Members of the SaPI family of S. aureus mobile elements encode superantigens and are mobilized at high frequency …
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Identification and Characterization of Helper Phage Gene Products Involved in Mobilization of Staphylococcal Pathogenicity Island SaPI1
Staphylococcal pathogenicity island SaPI1 is excised from genomic DNA and extrachromosomal copies are amplified during the vegetative growth of staphylococcal phage 80α. The amplified genetic element is subsequently encapsidated and transduced at very high frequency. Previous studies have …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
Salmonella Pathogenicity Island 1 (SPI1) encodes a Type-3 secretion system (T3SS) essential for Salmonella invasion of intestinal epithelial cells. Many environmental and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory …
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Role of the Small Terminase Subunit Encoded by Staphylococcus Aureus Pathogenicity Island SaPI1 in Formation of SaPI1 Transducing Particles
Staphylococcus aureus pathogenicity island SaPI1 is a genomic element that is mobilized and transduced at high frequency by helper phage 80α. SaPI1 encodes a small terminase protein that belongs to the phage small terminase subunit family. The presence of SaPI1-encoded small terminase suggests that …
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Coordinated regulation of the flagellar, Salmonella pathogenicity island 1, and the type I fimbriae gene networks in Salmonella typhimurium
Micro-organisms are constantly monitoring their surrounding environment and making important lifestyle decisions. This decision process is governed by large genetic networks that process the information leading to a phenotypic response from the cell. Using the food-borne pathogen, Salmonella, as a …
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Characterization of the type VI protein secretion system encoded in the Salmonella pathogenicity island 19 and its role in the pathogenicity of serotypes Gallinarum and Enteritidis
El genero Salmonella comprende a mas 2,500 serotipos conocidos distribuidos en dos especies: enterica y bongori. Estos serotipos difieren mucho en términos de patogenicidad y especificidad hospedero. Dos serotipos de Salmonella entérica son de especial relevancia: los serotipos Gallinarum y …
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Molecular characterisation of the Haemolysin (HlyA) and the Region Downstream of hlyA in Vibrio cholerae O1
… of the region flanking the hly locus suggests a pathogenicity island.
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Characterization of the Type III Effector VOPA from Vibrio Parahaemolyticus
… III secretion system (TTSS) encoded within a pathogenicity island. Within this pathogenicity island a homologue of the Yersinia type III effector YopJ was found and is referred to as VopA (Vibrio outer protein A). The founding member of the family, YopJ from Yersinia spp., inhibits the MAPK …
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Characterization of QSEA and QSED in the Quorum Sensing Cascade of Enterohemorrhagic Escherichia Coli
… for the activation of other genes within the pathogenicity island. The virulence mechanisms that enable EHEC to circumvent the host defenses and compete for essential nutrients for survival are controlled by several transcriptional regulators, many of which are controlled in response to quorum …
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Knockout of the trans-acting riboswitches in Listeria monocytogenes to disrupt downstream virulence factors
… (UTR) of the prfA gene located on the LIPI-1 pathogenicity island of the L. monocytogenes.</p>
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Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB
… cells is mediated by the <em>Salmonella</em>pathogenicity island 1 (SPI1) encoded type III secretion system (T3SS), a needle-like complex composed of over 20 proteins that translocates effector proteins directly into the host cell cytosol. <em>Salmonella</em> possess a second type III …
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A genetic screen to identify novel Helicobacter pylori virulence factors using Saccharomyces cerevisiae as a model eukaryotic cell
… of H pylori contain a 40-kb cytotoxin-associated pathogenicity island (cag PAl) that encodes and secretes the CagA protein into host epithelial cells via a type IV secretion system. To date, CagA is the only identified effector protein of the cag PAI. The goal of this study was to identify novel H …
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Helicobacter pylori gene regulation by virulence region located sRNAs
… DNA region called the cytotoxin associated gene pathogenicity island (cagPAI) that encodes virulence factors. Gastrointestinal disease associated with H. pylori are more likely to occur in infections with cagPAI positive strains. Helicobacter pylori has few known transcriptional regulators, but …
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