Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"pathogenic Th17 cells"”.
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… from the overly activation of tissue-resident T-cells in response to a dysbiotic composition of the gut microbiota. In particular, the pathogenesis of CD has been linked to a significant enrichment of pathogenic IFNγ-producing Th17 cells with a concomitant selective and significant enrichment of …
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T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
… for BCAP in the TLR signaling pathway in myeloid cells. Due to the shared use of TIR domains by TLR and IL1R signaling pathways, I hypothesized that BCAP would also be involved in signaling downstream of the IL1 family of receptors. The IL1 cytokine family has been shown to play a major role in T …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… significance of transcriptional regulation of Th cells in MS pathogenesis, we investigated the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, …
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The Role of the IL-23/Th17/IL-17 Axis in the Pathophysiology of Endometriosis
… and progression. Notably, the IL-23/Th17/IL-17 axis is significantly altered in EM and associated with disease severity. This is notable as in other chronic inflammatory diseases, IL-23 drives pathogenic Th17 responses, producing IL-17 to exacerbate disease. Th17 cells are also highly …
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The impact of viral infection during pregnancy on maternal immunity and fetal brain development
… strain of IAV: (1) maternal adaptive immune cells, T helper 17 (TH17) lymphocytes, and their effector cytokine, IL-17, drive inflammatory cascades that signal to the fetal brain and induce neocortical malformations, and (2) fetal brain-resident macrophages respond to maternal viral …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
… with a dysregulated activation of the IL-23/pTh17 axis, is a distinctive feature of CD. In this context, current therapies primarily suppress the exaggerated inflammation without directly targeting AIEC, and the only AIEC-based approach under investigation is the inhibition of FimH, which …